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RISS 인기검색어
- 검색키워드
- 저자 : Ryuge, Shinichiro (검색결과 4 건)
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Yanagita, Kengo,Nagashio, Ryo,Ryuge, Shinichiro,Katono, Ken,Jiang, Shi-Xu,Tsuchiya, Benio,Nakashima, Hiroyasu,Fukuda, Eriko,Goshima, Naoki,Saegusa, Makoto,Satoh, Yukitoshi,Masuda, Noriyuki,Sato, Yuich Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17
Background: Identification of predictive markers for the efficacy of platinum-based chemotherapy is necessary to improve the quality of the life of cancer patients. Materials and Methods: We detected proteins recognized by autoantibodies in pretreated sera from patients with lung adenocarcinoma (AC) evaluated as showing progressive disease (PD) or a partial response (PR) after cisplatin-based chemotherapy by proteomic analysis. Then, the levels of the candidate autoantibodies in the pretreated serum were validated by dot-blot analysis for 22 AC patients who received platinum-based chemotherapy, and the expression of identified proteins was immunohistochemically analyzed in 40 AC biopsy specimens. Results: An autoantibody against galectin-3 (Gal-3) was detected in pretreated sera from an AC patient with PD. Serum IgG levels of anti-Gal-3 autoantibody were significantly higher in patients evaluated with PD than in those with PR and stable disease (SD) (p = 0.0084). Furthermore, pretreated biopsy specimens taken from patients evaluated as showing PD following platinumbased chemotherapy showed a tendency to have a higher positive rate of Gal-3 than those with PR and SD (p = 0.0601). Conclusions: These results suggest that serum IgG levels of anti-Gal-3 autoantibody may be useful to predict the efficacy of platinum-based chemotherapy for patients with lung AC.
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S100A16 is a Prognostic Marker for Lung Adenocarcinomas
Saito, Keita,Kobayashi, Makoto,Nagashio, Ryo,Ryuge, Shinichiro,Katono, Ken,Nakashima, Hiroyasu,Tsuchiya, Benio,Jiang, Shi-Xu,Saegusa, Makoto,Satoh, Yukitoshi,Masuda, Noriyuki,Sato, Yuichi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16
Background: Many functional molecules controlling diverse cellular function are included in low-molecular weight proteins and peptides. Materials and Methods: To identify proteins controlling function in lung adenocarcinomas (AC), we performed two-dimensional gel electrophoresis employing tricine-SDS polyacrylamide in the second dimension (tricine 2-DE). This system was able to detect proteins under 1 kDa even with post-translational modifications. To confirm the utility of detected proteins as novel tumor markers for AC, we performed immunohistochemical analysis using 170 formalin-fixed and paraffin-embedded lung AC tissues. Results: Tricine 2-DE revealed that five proteins including S100A16 were overexpressed in lung AC-derived cells compared with lung squamous cell carcinoma, small cell carcinoma, and large cell neuroendocrine carcinoma-derived cells. Immunohistochemically, S100A16 showed various subcellular localization in lung cancer tissues and a membranous staining status was correlated with the T-factor (P=0.0008), pathological stage (P=0.0015), differentiation extent (P=0.0001), lymphatic invasion (P=0.0007), vascular invasion (P=0.0001), pleural invasion (P=0.0087), and gender (P=0.039), but not with the age or smoking history. More importantly, membranous staining of S100A16 was significantly correlated with a poorer overall survival of either stage I (P=0.0088) or stage II / III (P=0.0003) lung AC patients, and multivariate analysis confirmed that membranous expression of S100A16 was an independent adverse prognostic indicator (P=0.0001). Conclusions: The present results suggest that S100A16 protein is a novel prognostic marker for lung AC.
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Clinicopathological Significance of S100A10 Expression in Lung Adenocarcinomas
Katono, Ken,Sato, Yuichi,Jiang, Shi-Xu,Kobayashi, Makoto,Saito, Keita,Nagashio, Ryo,Ryuge, Shinichiro,Satoh, Yukitoshi,Saegusa, Makoto,Masuda, Noriyuki Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.1
Background: S100A10, of the S100 protein family, is reported to be involved in cancer cell invasion and metastasis. The aims of the present study were to immunohistochemically examine S100A10 expression in surgically resected lung adenocarcinomas, and evaluate any relationships with clinicopathological parameters and prognosis of patients. Materials and Methods: S100A10 expression was immunohistochemically studied in 202 consecutive resected lung adenocarcinomas, and its associations with clinicopathological parameters were evaluated. Kaplan-Meier survival analysis and Cox proportional hazards models were used to estimate the effect of S100A10 expression on survival. Results: S100A10 expression was detected in 65 of the 202 (32.2%) lung adenocarcinomas, being significantly correlated with poorer differentiation (P =0.015), a higher pathological TNM stage (stages II and III) (P=0.004), more frequent and severe intratumoral vascular invasion (P=0.001), and a poorer prognosis (P=0.030). However, S100A10 expression was not an independent predictor of survival after controlling for clinicopathological factors. Conclusions: The present study reveals that S100A10 is expressed in a subset of lung adenocarcinomas, and this is related to some clinicopathological parameters, although further studies are required to confirm the correlation between S100A10 expression and prognosis of lung adenocarcinoma patients.
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효과적인 MC-BCS-SPL 알고리즘과 예측 구조 방식에 따른 성능 비교
류중선,김진수,Ryug, Joong-seon,Kim, Jin-soo 한국정보통신학회 2017 한국정보통신학회논문지 Vol.21 No.7
Recently, distributed compressed video sensing (DCVS) has been actively studied in order to achieve a low complexity video encoder by integrating both compressed sensing and distributed video coding characteristics. Conventionally, a motion compensated block compressed sensing with smoothed projected Landweber (MC-BCS-SPL) has been considered as an effective scheme of DCVS with all compressed sensing frames pursuing the simplest sampling. In this scheme, video frames are separately classified into key frames and WZ frames. However, when reconstructing WZ frame with conventional MC-BCS-SPL scheme at the decoder side, the visual qualities are poor for temporally active video sequences. In this paper, to overcome the drawbacks of the conventional scheme, an enhanced MC-BCS-SPL algorithm is proposed, which corrects the initial image with reference to the key frame using a high correlation between adjacent key frames. The proposed scheme is analyzed with respect to GOP (Group of Pictures) structuring method. Experimental results show that the proposed method performs better than conventional MC-BCS-SPL in rate-distortion. 최근에 낮은 복잡도의 부호화기를 구현하기 위해 분산 비디오 부호화 와 압축센싱을 결합한 구조로서 분산 압축 비디오 센싱기술에 대한 연구가 활발히 진행되고 있다. 기존에 움직임 보상 블록 압축센싱 기술(MC-BCS-SPL)은 가장 간단한 표본화를 추구하면서 모든 압축센싱 프레임을 갖는 DCVS방식중의 효과적인 방안으로 다루어져 왔다. 이 방식은 키 프레임과 WZ 프레임으로 분리하여 압축센싱한다. 그러나 MC-BCS-SPL 방식은 복호화기에서 WZ 프레임을 복원할 때, 움직임이 큰 영상 시퀀스의 경우에 화질 저하가 발생시키는 단점이 존재한다. 본 논문에서는 이러한 기존의 문제점을 극복하기 위한 개선된 MC-BCS-SPL 방식을 제안한다. 제안한 방식은 연속적인 키 프레임 간 에 존재하는 높은 상관관계를 이용하여 키 프레임을 참조함으로써 초기 영상을 보정한다. GOP 예측 구조 방식에 따른 율-왜곡 성능을 비교한다. 다양한 실험 결과를 통하여 제안하는 알고리즘이 기존 알고리즘보다 더 좋은 화질을 제공함을 보여준다.
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