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      • SCIESCOPUSKCI등재

        Spinosin Inhibits Aβ<sub>1-42</sub> Production and Aggregation via Activating Nrf2/HO-1 Pathway

        ( Xiaoying Zhang ),( Jinyu Wang ),( Guowei Gong ),( Ruixin Ma ),( Fanxing Xu ),( Tingxu Yan ),( Bo Wu ),( Ying Jia ) 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.3

        The present research work primarily investigated whether spinosin has the potential of improving the pathogenesis of Alzheimer’s disease (AD) driven by β-amyloid (Aβ) overproduction through impacting the procession of amyloid precursor protein (APP). Wild type mouse Neuro-2a cells (N2a/WT) and N2a stably expressing human APP695 (N2a/APP695) cells were treated with spinosin for 24 h. The levels of APP protein and secreted enzymes closely related to APP procession were examined by western blot analysis. Oxidative stress related proteins, such as nuclear factor-erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) were detected by immunofluorescence assay and western blot analysis, respectively. The intracellular reactive oxygen species (ROS) level was analyzed by flow cytometry, the levels of Aβ<sub>1-42 </sub>were determined by ELISA kit, and Thioflavin T (ThT) assay was used to detect the effect of spinosin on Aβ<sub>1-42 </sub>aggregation. The results showed that ROS induced the expression of ADAM10 and reduced the expression of BACE1, while spinosin inhibited ROS production by activating Nrf2 and up-regulating the expression of HO-1. Additionally, spinosin reduced Aβ<sub>1-42 </sub>production by impacting the procession of APP. In addition, spinosin inhibited the aggregation of Aβ<sub>1-42</sub>. In conclusion, spinosin reduced Aβ<sub>1-42</sub> production by activating the Nrf2/HO-1 pathway in N2a/WT and N2a/ APP695 cells. Therefore, spinosin is expected to be a promising treatment of AD.

      • KCI등재

        Thrust Ripple Suppression Strategy for Precision Machining Platform by Using Predicted Current Sliding Control

        Jiqiang Yu,Weirui Liu,Zheng Zhang,Xingjun Gao,Ruixin Bao 한국정밀공학회 2024 International Journal of Precision Engineering and Vol.25 No.10

        This paper focuses on solving the problem of the thrust ripple of the permanent magnet linear synchronous motor (PMLSM) to improve the machining accuracy and stability of the precision platform. The air gap magnetic field model of the permanent magnet magnetic field and the armature permanent magnet magnetic field are established using the equivalent magnetization method and the equivalent current method. The mathematical model of the linear motor is then derived using Clark and Park coordinate transformation. Also, the dynamic equation of the linear motor is developed considering the influence of electromagnetic thrust, detent force, and friction force. The error expressions resulting from thrust ripple are provided. To eliminate the thrust ripple and enhance the accuracy of the linear motor, a linear thrust observer is utilized to compensate for the low-frequency thrust ripple. The compensation current for the thrust ripple is then incorporated into the servo system using a new sliding mode controller. Additionally, a double T-Notch filter is designed to eliminate the interference signal caused by occasional resonance at a specific frequency, thereby ensuring the stability of the system output. Finally, experimental validation is conducted to verify the effectiveness of the proposed strategy, and the results demonstrate a significant improvement in thrust fluctuation and tracking accuracy.

      • SCIESCOPUSKCI등재

        Involvement of Estrogen Receptor-α in the Activation of Nrf2-Antioxidative Signaling Pathways by Silibinin in Pancreatic β-Cells

        ( Chun Chu ),( Xiang Gao ),( Xiang Li ),( Xiaoying Zhang ),( Ruixin Ma ),( Ying Jia ),( Dahong Li ),( Dongkai Wang ),( Fanxing Xu ) 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.2

        Silibinin exhibits antidiabetic potential by preserving the mass and function of pancreatic β-cells through up-regulation of estrogen receptor-α (ERα) expression. However, the underlying protective mechanism of silibinin in pancreatic β-cells is still unclear. In the current study, we sought to determine whether ERα acts as the target of silibinin for the modulation of antioxidative response in pancreatic β-cells under high glucose and high fat conditions. Our in vivo study revealed that a 4-week oral administration of silibinin (100 mg/kg/day) decreased fasting blood glucose with a concurrent increase in levels of serum insulin in high-fat diet/streptozotocin- induced type 2 diabetic rats. Moreover, expression of ERα, NF-E2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) in pancreatic β-cells in pancreatic islets was increased by silibinin treatment. Accordingly, silibinin (10 μM) elevated viability, insulin biosynthesis, and insulin secretion of high glucose/palmitate-treated INS-1 cells accompanied by increased expression of ERα, Nrf2, and HO-1 as well as decreased reactive oxygen species production in vitro. Treatment using an ERα antagonist (MPP) in INS-1 cells or silencing ERα expression in INS-1 and NIT-1 cells with siRNA abolished the protective effects of silibinin. Our study suggests that silibinin activates the Nrf2-antioxidative pathways in pancreatic β-cells through regulation of ERα expression.

      • KCI등재

        Optimal type and ratio of foaming agent, foaming stabilizer and fluxing agent of foam glass fabricated with red mud and coal gangue

        Jina Wang, Kaidong Xu,Zhixin Li,Yilong Yang,Qingxiao Li,Yun Bao,Huan Yang,Lingling Ding,Ruixin Zhang,Yuanyuan Wang,Lan Yao 한양대학교 세라믹연구소 2022 Journal of Ceramic Processing Research Vol.23 No.1

        In order to effectively reuse red mud and coal gangue, foam glass was successfully prepared by sintering. The foaming of foamglass is ensured by adding foaming agent, foam stabilizer and fluxing agent to the raw materials including red mud, coalgangue and waste glass. Furthermore, the defects in the foam glass are also reduced. The obtained powder was dried at 105ºC and characterized by XRF, DSC-TG analysis, etc. According to cellular structure, apparent density and water absorption,the optimal type and ratio of foaming agent, foaming stabilizer and fluxing agent were revealed. The results indicate that theoptimized formula of foaming agent, foaming stabilizer and fluxing agent is 3% MnO2-2% Na3PO4-2% borax. The foam glassprepared under optimized conditions exhibits uniform porous distribution and suitable pore size with an apparent density of0.575 g/cm3 and water absorption of 4.61%. The research in this work could establish the technical foundation of red mudbasedporous material for industrial production.

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