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Evgeniya D. Rubinshtein 한국로고스경영학회 2009 한국로고스경영학회 학술발표대회논문집 Vol.2009 No.7월
The fishing industry has the leading place in the industry of Russian Far East. During 90th the fishing industry there was in crises stage. However the Far East of Russia has a great potential for the fishing industry development. An investment activity can guaranty the growth, and these investments have to be effective. Therefore, the problem of the distribution of investments becomes crucial, and we are interested in the solution for this problem as a multi-criteria problem, which has to he solved in two-stages. We are to develop the complex of models for the first stage, including optimization models, statistical models and direct computations.
A Tetra(Ethylene Glycol) Derivative of Benzothiazole Aniline Enhances Ras-Mediated Spinogenesis
Megill, Andrea,Lee, Taehee,DiBattista, Amanda Marie,Song, Jung Min,Spitzer, Matthew H.,Rubinshtein, Mark,Habib, Lila K.,Capule, Christina C.,Mayer, Michael,Turner, R. Scott,Kirkwood, Alfredo,Yang, Jer Society for Neuroscience 2013 The Journal of neuroscience Vol.33 No.22
<P>The tetra(ethylene glycol) derivative of benzothiazole aniline, BTA-EG<SUB>4</SUB>, is a novel amyloid-binding small molecule that can penetrate the blood–brain barrier and protect cells from Aβ-induced toxicity. However, the effects of Aβ-targeting molecules on other cellular processes, including those that modulate synaptic plasticity, remain unknown. We report here that BTA-EG<SUB>4</SUB> decreases Aβ levels, alters cell surface expression of amyloid precursor protein (APP), and improves memory in wild-type mice. Interestingly, the BTA-EG<SUB>4</SUB>-mediated behavioral improvement is not correlated with LTP, but with increased spinogenesis. The higher dendritic spine density reflects an increase in the number of functional synapses as determined by increased miniature EPSC (mEPSC) frequency without changes in presynaptic parameters or postsynaptic mEPSC amplitude. Additionally, BTA-EG<SUB>4</SUB> requires APP to regulate dendritic spine density through a Ras signaling-dependent mechanism. Thus, BTA-EG<SUB>4</SUB> may provide broad therapeutic benefits for improving neuronal and cognitive function, and may have implications in neurodegenerative disease therapy.</P>
Lee, N.J.,Song, J.M.,Cho, H.J.,Sung, Y.M.,Lee, T.,Chung, A.,Hong, S.H.,Cifelli, J.L.,Rubinshtein, M.,Habib, L.K.,Capule, C.C.,Turner, R.S.,Pak, D.T.S.,Yang, J.,Hoe, H.S. Elsevier Science Publishers B.V 2016 Biochimica et biophysica acta Vol.1862 No.2
Our recent study demonstrated that an amyloid-β binding molecule, BTA-EG4, increases dendritic spine number via Ras-mediated signaling. To potentially optimize the potency of the BTA compounds, we synthesized and evaluated an amyloid-β binding analog of BTA-EG4 with increased solubility in aqueous solution, BTA-EG6. We initially examined the effects of BTA-EG6 on dendritic spine formation and found that BTA-EG6-treated primary hippocampal neurons had significantly increased dendritic spine number compared to control treatment. In addition, BTA-EG6 significantly increased the surface level of AMPA receptors. Upon investigation into the molecular mechanism by which BTA-EG6 promotes dendritic spine formation, we found that BTA-EG6 may exert its effects on spinogenesis via RasGRF1-ERK signaling, with potential involvement of other spinogenesis-related proteins such as Cdc42 and CDK5. Taken together, our data suggest that BTA-EG6 boosts spine and synapse number, which may have a beneficial effect of enhancing neuronal and synaptic function in the normal healthy brain.