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Tissue Engineering of Articular Cartilage: From Bench to Bed-side
Rozlin Abdul Rahman,Muhammad Aa’zamuddin Ahmad Radzi,Norhamiza Mohamad Sukri,Noorhidayah Md Nazir,Munirah Sha’ban 한국조직공학과 재생의학회 2015 조직공학과 재생의학 Vol.12 No.1
Degeneration or defect of articular cartilage is a major predicament and if it is left untreated, it may leadto progressive damage and disability affecting every one disregard of their age. Although nonsurgical managementof articular cartilage injury has remained largely the same over many years, surgical treatment keeps on evolving. Restorative techniques, mainly the cell-based therapies and autologous or allograft transplants continue to expand,giving surgeons more options for biologic reconstruction of the articular surfaces. Hence the field of articular cartilagetissue engineering which seeks to repair, restore and improve injured or diseased articular cartilage functionalityhas aroused deep interest and holds great potential for improving articular cartilage therapy. However despite thisgreat evolution, therapeutic uncertainty in the restoration of damaged cartilage using tissue engineering approachesstill remains unclear for the surgeon treating patients to make evidence-based decisions. This paper will give a generalidea to different level of audiences in understanding the concept of tissue engineering from bench to bed-sideregarding recent developments in this exciting field.