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Immunohistochemistry and molecular biology of bone and soft tissue sarcomas with epithelial features
Rikuo Machinami 가톨릭중앙의료원 가톨릭암센터 1997 암심포지움 Vol.- No.1
Adamantinoma of long bones and synovial sarcoma are bone and soft tissue sarcomas with epithelial features. Adamantinoma(AD) of long bones is a rare malignant bone tumor and occurs predominantly in the tibia.
Molecular biological approach to pathology of osteosarcoma
Rikuo Machinami 가톨릭중앙의료원 가톨릭암센터 1997 암심포지움 Vol.- No.1
It has been believed that oncogenes play an important role in tumorigenesis, progression, clonality, diagnosis, distinction between benign and malignant, grades of malignancy, prognosis and gene therapy of neoplasmas. Abnormality of p53 gene has been well known in Li-Fraumeni syndrome in which osteosarcoma occurs together with breast cancer. It is also well known that osteosarcoma sometimes occurs in patients with retinoblastoma showing abnormality of RB gene. Therefore we have examined the role of p53 and RB genes in biological behavior of osteosarcoma by molecular biological technique.
Morphometry, cytogenetics and molecular biology in diagnosis of chondroid tumors
Rikuo Machinami 가톨릭중앙의료원 가톨릭암센터 1997 암심포지움 Vol.- No.1
Several subtypes of chondrosarcoma including dedifferentiated, clear cell, mesenchymal juxtacortical and secondary chondrosarcomas are well known in addition to conventional chondrosarcoma. Conventional chondrosarcomas are graded histologically into 3 grades of malignancy.