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- 저자 : Riko Nishimura (검색결과 4 건)
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Regulation of Cartilage Development and Diseases by Transcription Factors
Riko Nishimura,Kenji Hata,Yoshifumi Takahata,Tomohiko Murakami,Eriko Nakamura,Hiroko Yagi 대한골대사학회 2017 대한골대사학회지 Vol.24 No.3
Genetic studies and molecular cloning approaches have been successfully used to identify several transcription factors that regulate the numerous stages of cartilage development. Sex-determining region Y (SRY)-box 9 (Sox9) is an essential transcription factor for the initial stage of cartilage development. Sox5 and Sox6 play an important role in the chondrogenic action of Sox9, presumably by defining its cartilage specificity. Several transcription factors have been identified as transcriptional partners for Sox9 during cartilage development. Runt-related transcription factor 2 (Runx2) and Runx3 are necessary for hypertrophy of chondrocytes. CCAAT/enhancer-binding protein β (C/EBPβ) and activating transcription factor 4 (ATF4) function as co-activators for Runx2 during hypertrophy of chondrocytes. In addition, myocyte-enhancer factor 2C (Mef2C) is required for initiation of chondrocyte hypertrophy, presumably by functioning upstream of Runx2. Importantly, the pathogenic roles of several transcription factors in osteoarthritis have been demonstrated based on the similarity of pathological phenomena seen in osteoarthritis with chondrocyte hypertrophy. We discuss the importance of investigating cellular and molecular properties of articular chondrocytes and degradation mechanisms in osteoarthritis, one of the most common cartilage diseases.
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Effect of empathy trait on attention to faces
Damee Choi,Takayuki Nishimura,Midori Motoi,Yuka Egashira,Riko Matsumoto,Shigeki Watanuki 대한인간공학회 2014 대한인간공학회 학술대회논문집 Vol.2014 No.5
To extend knowledge of relationship between empathy trait and attention to face, the present study aimed at investigating relationship between self-reported empathy trait and N170 elicited by five facial expressions (happy, angry, surprised, afraid, and sad). Twenty-two participants (12 males and 10 females) discriminated those five facial expressions from emotionally neutral faces under an oddball paradigm while event-related potentials (ERP) were recorded. The empathy trait of participants was measured using the Interpersonal Reactivity Index (IRI, Davis, 1980). The results revealed that participants with high IRI score showed more negative amplitude of N170 (140 to 200 ms after stimulus onset) than those with low IRI score at posterior temporal area in response to happy, angry, surprised, and afraid faces. The present study thus suggests that people with high empathy trait pay attention to faces more than those with low empathy, in very early stage of processing of face with happy, angry, surprised, and afraid expressions. Furthermore, this also indicates that empathy trait is related with attention processing of not only negative expressions (angry and afraid) but also positive (happy) and ambiguous expression (surprised).
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Effect of Empathy Trait on Attention to Faces: Evidence from N170
( Damee Choi ),( Takayuki Nishimura ),( Midori Motoi ),( Yuka Egashira ),( Riko Matsumoto ),( Shigeki Watanuki ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-
To extend knowledge of relationship between empathy trait and attention to face, the present study aimed at investigating relationship between self-reported empathy trait and N170 elicited by five facial expressions (happy, angry, surprised, afraid, and sad). Twenty-two participants (12 males and 10 females) discriminated those five facial expressions from emotionally neutral faces under an oddball paradigm while event-related potentials (ERP) were recorded. The empathy trait of participants was measured using the Interpersonal Reactivity Index (IRI, Davis, 1980). The results revealed that participants with high IRI score showed more negative amplitude of N170 (140 to 200 ms after stimulus onset) than those with low IRI score at posterior temporal area in response to happy, angry, surprised, and afraid faces. The present study thus suggests that people with high empathy trait pay attention to faces more than those with low empathy, in very early stage of processing of face with happy, angry, surprised, and afraid expressions. Furthermore, this also indicates that empathy trait is related with attention processing of not only negative expressions (angry and afraid) but also positive (happy) and ambiguous expression (surprised).
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Transcriptional Network Controlling Endochondral Ossification
Kenji Hata,Yoshifumi Takahata,Tomohiko Murakami,Riko Nishimura 대한골대사학회 2017 대한골대사학회지 Vol.24 No.2
Endochondral ossification is the fundamental process of skeletal development in vertebrates. Chondrocytes undergo sequential steps of differentiation, including mesenchymal condensation, proliferation, hypertrophy, and mineralization. These steps, which are required for the morphological and functional changes in differentiating chondrocytes, are strictly regulated by a complex transcriptional network. Biochemical and mice genetic studies identified chondrogenic transcription factors critical for endochondral ossification. The transcription factor sex-determining region Y (SRY)-box 9 (Sox9) is essential for early chondrogenesis, and impaired Sox9 function causes severe chondrodysplasia in humans and mice. In addition, recent genome-wide chromatin immunoprecipitation-sequencing studies revealed the precise regulatory mechanism of Sox9 during early chondrogenesis. Runt-related transcription factor 2 promotes chondrocyte hypertrophy and terminal differentiation. Interestingly, endoplasmic reticulum (ER) stress-related transcription factors have recently emerged as novel regulators of chondrocyte differentiation. Here we review the transcriptional mechanisms that regulate endochondral ossification, with a focus on Sox9.
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