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A study of Disaster Survivors in Korea
MinSoo Lee,RheeHun Kang,ByungJoo Ham,YunKyeung Choi,ChangSu Han,HeonJeong Lee,SeungHwan Lee,SungMee Kim,HongSeock Lee 대한신경정신의학회 2004 PSYCHIATRY INVESTIGATION Vol.1 No.1
Objectives-The purpose of this study was to assess the clinical manifestation of psychiatric symptoms and Minnesota Multiphasic Personality Inventory (MMPI) profiles, and to examine the factors affecting the Degree of symptom severity, among survivors of a man-made disaster in Korea. Methods-Survivors of the Sampoong Department Store collapse were evaluated in October 1995, 5 months after the disaster occurred. Among the original 681 subjects, 624 were evaluated using the Psychiatric Evaluation Form, and the MMPI. Results-The primary complaint was sleep disturbance (54.2%), which was followed by headaches (31.8%) and intense distress over reminders of the event (24.2%). Most subjects (90.4%) showed a variety of psychiatric symptoms with certain factors further affecting the degree of severity. Another result showed that the severity of the subjects symptoms increased as their age increased and their educational level decreased. Divorced and widowed survivors had more severe symptoms, as did those who had experienced a loss of consciousness or who had waited a long time to be rescued. In the MMPI, the mean Welsh code profile configuration was 13726-0894/5: F-KL: and the most common two- and three- point code types were 1-3/3-1 (15.4%) and 1-3-7/1-7-3 (8.4%), respectively. Conclusions-The results indicate that it is possible to identify the specific psychiatric symptoms that resulted from this disaster, and that a substantial segment of the adult population exposed to similar events may experience symptoms of post traumatic stress. The psychiatric symptoms and the factors affecting the severity of the symptoms identified in this study may prove useful in the future screening of disaster victims for appropriate evaluation and treatment.
Association between Serotonin 2A Receptor Gene Polymorphism and Posttraumatic Stress Disorder
HeonJeong Lee,SangKon Kwak,JongWoo Paik,RheeHun Kang,MinSoo Lee 대한신경정신의학회 2007 PSYCHIATRY INVESTIGATION Vol.4 No.2
Objective-The present study examined the possible association between the serotonin 2A receptor (5-HTR2A)-1438 A/G polymorphism and post-traumatic stress disorder (PTSD). Methods-The genotype, allele and allele carrier frequencies of the 5-HTR2A gene polymorphism were analyzed in 107 PTSD patients and 161 unrelated healthy controls using a case-control design. Results-While there was no difference in the genotype and allele distribution of the 5-HTR2A gene polymorphism between the PTSD patients and normal controls, there was a marginal difference in the allele carrier frequency between the two groups (χ2=2.82, df=1, p=0.093), that is the GG genotype frequency tended to be higher in the PTSD samples. When the analyses were conducted separately by gender, the frequency of the GG genotype was significantly higher in the female PTSD patients than in the female normal controls (χ2=4.38, df=1, p=0.036; OR=2.21, 95% confidence interval: 1.04-4.71). Conclusion-These findings suggest that the 5-HTR2A GG genotype is one of the possible genetic factors for susceptibility to PTSD, especially in the female population. Further investigations are required into the influence of gene polymorphisms on the biological mechanisms of PTSD.