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RISS 인기검색어
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- 저자 : Ranjitha V. R. (검색결과 2 건)
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Selenium nanostructure: Progress towards green synthesis and functionalization for biomedicine
Ranjitha V. R.,Rai V. Ravishankar 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.2
Background Selenium is a pivotal micronutrient required for the proper functioning of the body. Deficiency of Se leads to various diseases whereas a high dosage of Se possesses toxicity. To reduce the toxic effects of elemental selenium and to maximize its efficacy, synthesis of selenium at the nanoscale level is important. Selenium nanoparticles (SeNPs) have received considerable attention in the past few decades. Synthesis of nano selenium with unique properties is necessary for its biomedical applications. Synthesis steps involve physical, chemical and biological methods. The biological or green synthesis method is often more advantageous than other available methods because of the major drawbacks involved in those methods. Area covered SeNPs synthesised through green route, such as microbes and plants, are summarized in this review. Synthesised SeNPs that is functionalized with different biological moieties are discussed and listed. Green synthesis involves the use of eco-friendly plants and microbes as the route for the synthesis. SeNPs are non-toxic and stable due to the natural capping agent that prevents protein aggregation and maintains the stability of the nanoparticles. Expert opinion To achieve targeted drug delivery of the synthesized nanomaterials and to increase the efficacy of the SeNPs with minimal toxicity, functionalization is an essential tool in the field of nanomedicine. Functionalized SeNPs with various biological moieties offer enhanced cytotoxicity against various cancer cell lines, good stability and targeted drug delivery without non-specific interaction compared to nanoparticle alone. The present review focuses on detailed report and progress towards the green approach for SeNPs synthesis and engineering selenium nanomaterials with different moieties possibly used for various biomedical applications.
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R. Asokan,K. B. REBIJITH,H. H. RANJITHA,H. K. ROOPA,V.V. Ramamurthy 한국곤충학회 2013 Entomological Research Vol.43 No.4
MicroRNAs (miRNAs) are a family of small, endogenously initiated non‐coding RNAs that extensively regulate gene expression either by mRNA cleavage or by translational repression, thus playing important roles in the development and physiology of organisms. Experimental identification and characterization of spatially and temporally expressed miRNAs is a monumental task in insects such as the brown plant hopper, Nilaparvata lugens, a major pest of rice and also a vector of Tenuivirus. At this juncture bioinformatics approaches, which primarily depend on sequence homology and secondary structure verification, will be an invaluable tool. A total of nine novel miRNAs were identified in N. lugens using the computational approaches from 1 13 718 Expressed Sequence Tags. The phylogenetic analysis was carried out to compare their level of conservation with respect to other members of the animal kingdom. The functional annotation of these newly identified miRNAs revealed that the majority of them are involved in the transcription regulatory activity and signal transduction pathways. These regulatory impacts are promising towards insect pest management but need further experimental validation and functional analyses. Thus, the outcome of this study will help to carry out the gene knockdown and transgenesis studies for the functional analysis of the newly identified miRNA‐regulated phenotypes in N. lugens.
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