http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Rajnendrapal Kaur (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Participation of α2 Receptors in the Antinociceptive Activity of Quercetin
Kanwaljit Chopra,Rajnendrapal Kaur,Devinder Singh 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.4
The present work was planned to evaluate the antinociceptive activity of quercetin, its site of action, and the involvement of adrenergic receptors in mediating the antinociceptive activity in thermal and chemonociceptive assays. Eight groups were employed in this study: Groups I, II, and III received quercetin alone in different doses, group IV animals were administered clonidine, group V animals were co-administered quercetin and clonidine, group VI animals were administered yohimbine 30 minutes prior to administratin of quercetin, group VII animals were administered yohimbine 30 minutes prior to co-administration of quercetin and clonidine, and group VIII animals were administered 0.5% carboxymethylcellulose in saline (vehicle for quercetin). The thermal nociception was measured by tail flick and hot plate methods. Quercetin produced a significant analgesic effect in a dose-dependent manner. Co-administration of low doses of quercetin and clonidine produced a synergistic analgesic effect. Pretreatment with yohimbine significantly reversed quercetin-as well as clonidine/quercetin combination-induced effects. The results of this study reveal that quercetin induces an antinociceptive effect and that this effect involves primarily the modulation of adrenergic pathways.
-
Role of α2 Receptors in Quercetin-Induced Behavioral Despair in Mice
Devinder Singh,Rajnendrapal Kaur,Kanwaljit Chopra 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.1
Depression is a well-defined illness that afflicts a large population worldwide. Various biochemical theorieshave been described; however, the pathophysiology of depression is still poorly understood. The present study explores therole of a natural flavonoid, quercetin, in the forced swimming model of depression and its interaction with presynaptic .2adrenoceptors. Quercetin induced a significant behavioral despair, which was abrogated with pretreatment with yohimbine,an .2 adrenoceptor antagonist, and imipramine, a tricyclic antidepressant. The results of the study support the contention thatquercetin utilizes presynaptic .2 adrenoceptors in eliciting its depressant activity in mice.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
