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      저자 : Radipta Lailatussifa (검색결과 2 건)
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        Anti-stress Activity of Sargassum polycystum Extracts Using a Cold Restraint Stress Model

        Radipta Lailatussifa,Amir Husni,Agung Endro Nugroho 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.2

        Anti-stress effects of polyphenol extracts of Sargassum polycystum were evaluated. Polyphenol extracts of S. polycystum and diazepam were compared for anti-stress activities using a cold restraint animal stress model. S. polycystum extracts were administered orally at dosages of 150 and 450 mg/kg. Diazepam, an anti-stress agent, was used as a standard drug at 0.18 mg/kg p.o. Both dosages of S. polycystum extracts showed good anti-stress effects. Due to cold restraint stress there was an imbalance in levels of biochemical parameters, including glucose, triglycerides, cholesterol, alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate amino transferase (AST), which were near normalized following adminstration of S. polycystum extracts. Polyphenol extracts of S. polycystum at oral dosages of 150 and 450 mg/kg exerted anti-stress effects.

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        Sargassum hystrix as a Source of Functional Food to Improve Blood Biochemistry Profiles of Rats under Stress

        Amir Husni,Radipta Lailatussifa,Alim Isnansetyo 한국식품영양과학회 2019 Preventive Nutrition and Food Science Vol.24 No.2

        This study was conducted to determine the influence of Sargassum hystrix powder (SHP) as an alternative source of functional food for treating in vivo stress by measuring levels of glucose, triacylglycerol, total cholesterol, and cortisol, and liver histopathology. Wistar rats aged 3 months and weighing 150∼200 g were divided into 7 groups: normal control, fasting control, negative control (stress without adaptogen), and 4 experimental conditions (stress+0.18 ㎎/㎏ diazepam, stress+450 ㎎/㎏ pellet, stress+mixture of pellet with SHP 450 ㎎/㎏, and stress+450 ㎎/㎏ of SHP). Intake of liquids and and body weight were measured daily. Blood samples were collected on day 0 (baseline), day 5, and day 10 to analyze levels of glucose, triacylglycerol, cholesterol, and cortisol. On day 10, rats were euthanized and livers were collected to observe the severity of inflammation. The results indicated that rats receiving SHP 450 ㎎/㎏ and the mixture of pellet with SHP 450 ㎎/㎏ showed a similar ability as those receiving diazepam 0.18 ㎎/㎏ to cope with stress, indicated by an improvement in all blood biochemistry parameters. Supplementation with SHP 450 ㎎/㎏ can be used as an alternative source of functional food for overcoming oxidative stress, as indicated by its ability to improve levels of blood glucose, triacylglycerol, total cholesterol, and cortisol, and to improve liver histology by decreasing severity of liver inflammation.

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