http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Qiru Wang (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
SKF96365 impedes spinal glutamatergic transmission-mediated neuropathic allodynia
Qiru Wang,Yang Zhang,Qiong Du,Xinjie Zhao,Wei Wang,Qing Zhai,Ming Xiang 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.1
Spinal nerve injury causes mechanical allodynia and structural imbalance of neurotransmission, which were typically associated with calcium overload. Storeoperated calcium entry (SOCE) is considered crucial elements-mediating intracellular calcium homeostasis, ion channel activity, and synaptic plasticity. However, the underlying mechanism of SOCE in mediating neuronal transmitter release and synaptic transmission remains ambiguous in neuropathic pain. Neuropathic rats were operated by spinal nerve ligations. Neurotransmissions were assessed by whole-cell recording in substantia gelatinosa. Immunofluorescence staining of STIM1 with neuronal and glial biomarkers in the spinal dorsal horn. The endoplasmic reticulum stress level was estimated from qRT-PCR. Intrathecal injection of SOCE antagonist SKF96365 dose-dependently alleviated mechanical allodynia in ipsilateral hind paws of neuropathic rats with ED50 of 18 μg. Immunofluorescence staining demonstrated that STIM1 was specifically and significantly expressed in neurons but not astrocytes and microglia in the spinal dorsal horn. Bath application of SKF96365 inhibited enhanced miniature excitatory postsynaptic currents in a dosage-dependent manner without affecting miniature inhibitory postsynaptic currents. Mal-adaption of SOCE was commonly related to endoplasmic reticulum (ER) stress in the central nervous system. SKF96365 markedly suppressed ER stress levels by alleviating mRNA expression of C/ EBP homologous protein and heat shock protein 70 in neuropathic rats. Our findings suggested that nerve injury might promote SOCE-mediated calcium levels, resulting in long-term imbalance of spinal synaptic transmission and behavioral sensitization, SKF96365 produces antinociception by alleviating glutamatergic transmission and ER stress. This work demonstrated the involvement of SOCE in neuropathic pain, implying that SOCE might be a potential target for pain management
-
Qiru Dong,Xuelian Wang,Shuiyong Fan,Yinghua Li,Xiaobin Qiu,Lili Liu 한국기상학회 2022 Asia-Pacific Journal of Atmospheric Sciences Vol.58 No.5
The x and y components of wind (U and V, respectively) are widely used as control variables in radar assimilation; therefore,it is common to choose (U, V) as the control variables for multi-scale data assimilation (DA) in convective-scale. When themodel resolution reaches the convective scale, whether (U, V), as the momentum control variables, are still more suitablethan the stream function (ψ) and unbalanced velocity potential (χu), it needs to be studied further examination. This studyuses 3-km resolution forecast samples to calculate the background error covariance (B) with two different pairs of momentumcontrol variables ((ψ, χu) and (U, V)) by the National Meteorology Center (NMC) method. In single-observation experiments,the analysis wind field is most sensitive to the two pairs of B, and the temperature is insensitive. When using (U, V) as thecontrol variables, the local characteristic is more evident according to vertical and horizontal wind increments. The studyassimilates low- resolution conventional observations to compare different momentum control variables, (ψ, χu) and (U, V),in numerical simulation experiments of the torrential rainfall in North China. In addition, the impacts of the two controlvariables options are also compared in terms of the 15 continuous days of cases in flood season. The main results are as follows:(1) the wind field is the critical difference between the two assimilation experiments at the analysis time. Using (U, V)as the control variables, the analysis field of wind from both the surface and different vertical levels is superior. The analysisfield closer fits the wind observation; (2) the use of (U, V) control variables improves the short term (0~3-h) in surface windprediction; and (3) the use of (U, V) control variables enhances the 24-h TS (threat score) in moderate rain and heavy rain.
ScienceON
스콜라연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
