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- 저자 : Qingxi Hu (검색결과 1 건)
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Qingxi Hu,Qi Wang,Suihong Liu,Ye Lu,Zhaoxiang Zeng,Jiaxuan Feng,Rui Feng,Haiguang Zhang 한국섬유공학회 2023 Fibers and polymers Vol.24 No.2
Nowadays, many studies focus on the preparation of small-diameter vascular scaffolds, but some issues still existed that needto be urgently solved, but there are still problems such as slow endothelialization and failure to keep the vessels open for a longtime that need to be solved. In this paper, a composite process of preparing triple-layer vascular scaffolds with microchannelstructure in the inner layer is proposed to guide cell growth and accelerate the endothelialization process. The PCL patternwas printed as the intermediate layer of the vascular scaffold by 3D printing method, and the width of the microchannel inthe inner layer of the scaffold was controlled by the printing spacing. The inner and outer layers were prepared by electrospinning. Heparin is often used as an anticoagulant in vascular tissue engineering to improve the problem of thrombosisand blockage of vascular scaffold after transplantation into the body. Here, the inner layer carries heparin immobilized withsilk fibroin by coaxial electrospinning, so that heparin can be released slowly. The addition of silk fibroin also improvedthe hydrophilicity of PCL electrospinning film by water contact angle test. The mechanical properties of vascular scaffoldswith double intermediate layers (DIL) are better than those with single intermediate layers (SIL) and also better than pureelectrospinning scaffolds. In vitro cell experiments showed that cells grow directionally on microchannel structures of innerlayer and randomly on electrospinning film without microchannel structure. The results showed that the microchannels weremore conducive to cell growth and proliferation at a diameter of 0.25 mm. The composite electrospinning films with silkfibroin and heparin facilitated cell adhesion and proliferation compared to the pure PCL films. All these results indicate thatthe vascular scaffolds have potential applications in clinic for vascular tissue regeneration.
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