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Hans-Christoph BURMEISTER,Wilko BRUHN,Ørnulf Jan RØDSETH,Thomas PORATHE 국제이네비해양경제학회 2014 International Journal of e-Navigation and Maritime Vol.1 No.1
While IMO’s e-Navigation project’s scope is to enhance safety of navigation by improved shipto- shore-cooperation, the EU’s FP7 project MUNIN’s aim is to develop a concept for an autonomous dry bulk carrier, that is at least as safe as a manned vessel. As e-Navigation has a strong focus on improving the human element in shipping and MUNIN tends towards an unmanned bridge, a common baseline might look quite contradictory at first, but they share the need to ensure and enhance the safety of navigation. After an introduction into e-Navigation and the MUNIN project, this paper will demonstrate with two examples, how MUNIN’s results address identified e-Navigation’s gaps and addresses e-Navigation’s user needs. Thus, MUNIN contributes to the development and implementation of the prioritized e-Navigation solutions.
Mutations of CEP83 Cause Infantile Nephronophthisis and Intellectual Disability
Failler, M.,Gee, H.,Krug, P.,Joo, K.,Halbritter, J.,Belkacem, L.,Filhol, E.,Porath, Jonathan D.,Braun, Daniela A.,Schueler, M.,Frigo, A.,Alibeu, O.,Masson, C.,Brochard, K.,Hurault de Ligny, B.,Novo, R University of Chicago Press [etc.] 2014 American journal of human genetics Vol.94 No.6
Ciliopathies are a group of hereditary disorders associated with defects in cilia structure and function. The distal appendages (DAPs) of centrioles are involved in the docking and anchoring of the mother centriole to the cellular membrane during ciliogenesis. The molecular composition of DAPs was recently elucidated and mutations in two genes encoding DAPs components (CEP164/NPHP15, SCLT1) have been associated with human ciliopathies, namely nephronophthisis and orofaciodigital syndrome. To identify additional DAP components defective in ciliopathies, we independently performed targeted exon sequencing of 1,221 genes associated with cilia and 5 known DAP protein-encoding genes in 1,255 individuals with a nephronophthisis-related ciliopathy. We thereby detected biallelic mutations in a key component of DAP-encoding gene, CEP83, in seven families. All affected individuals had early-onset nephronophthisis and four out of eight displayed learning disability and/or hydrocephalus. Fibroblasts and tubular renal cells from affected individuals showed an altered DAP composition and ciliary defects. In summary, we have identified mutations in CEP83, another DAP-component-encoding gene, as a cause of infantile nephronophthisis associated with central nervous system abnormalities in half of the individuals.
SteelFisher, Gillian K,Blendon, Robert J,Kang, Minah,Ward, Johanna R M,Kahn, Emily B,Maddox, Kathryn EW,Lubell, Keri M,Tucker, Myra,Ben-Porath, Eran N BlackWell Publishing Ltd 2015 Influenza and other respiratory viruses Vol.9 No.3
<P><B>Background</B></P><P>As public health leaders prepare for possible future influenza pandemics, the rapid spread of 2009 H1N1 influenza highlights the need to focus on measures the public can adopt to help slow disease transmission. Such measures may relate to hygiene (e.g., hand washing), social distancing (e.g., avoiding places where many people gather), and pharmaceutical interventions (e.g., vaccination). Given the disproportionate impact of public health emergencies on minority communities in the United States, it is important to understand whether there are differences in acceptance across racial/ethnic groups that could lead to targeted and more effective policies and communications.</P><P><B>Objectives</B></P><P>This study explores racial/ethnic differences in the adoption of preventive behaviors during the 2009 H1N1 influenza pandemic.</P><P><B>Patients/Methods</B></P><P>Data are from a national telephone poll conducted March 17 to April 11, 2010, among a representative sample of 1123 white, 330 African American, 317 Hispanic, 268 Asian, and 262 American Indian/Alaska Native adults in the USA.</P><P><B>Results</B></P><P>People in at least one racial/ethnic minority group were more likely than whites to adopt several behaviors related to hygiene, social distancing, and healthcare access, including increased hand washing and talking with a healthcare provider (<I>P</I>-values <0·05). Exceptions included avoiding others with influenza-like illnesses and receiving 2009 H1N1 and seasonal influenza vaccinations. After we controlled the data for socioeconomic status, demographic factors, healthcare access, and illness- and vaccine-related attitudes, nearly all racial/ethnic differences in behaviors persisted.</P><P><B>Conclusions</B></P><P>Minority groups appear to be receptive to several preventive behaviors, but barriers to vaccination are more pervasive.</P>