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Maria Mariano,Pietro Donati,Norma Cameli,Flavia Pigliacelli,Aldo Morrone,Antonio Cristaudo 한국유방암학회 2021 Journal of breast cancer Vol.24 No.1
Ribociclib is a selective cyclin-dependent kinase (CDK) 4/6 inhibitor that has been approved in combination with endocrine therapy for the treatment of hormone receptor-positive/human epidermal growth factor 2-negative advanced or metastatic breast cancer. The main dermatological adverse events associated with CDK 4/6 inhibitors that are described in the literature include skin rash, an increased risk of alopecia, and stomatitis. Erythema dyschromicum perstans (EDP), also known as ashy dermatosis, is characterized by acquired small and large slate-gray hyperpigmented macules with erythematous borders. There are currently no published reports of EDP-like or pigmentary changes induced by CDK 4/6 inhibitors. This report describes the first case of EDP-like pigmentation associated with ribociclib therapy.
4f occupancy and magnetism of rare-earth atoms adsorbed on metal substrates
Singha, Aparajita,Baltic, Romana,Donati, Fabio,Wä,ckerlin, Christian,Dreiser, Jan,Persichetti, Luca,Stepanow, Sebastian,Gambardella, Pietro,Rusponi, Stefano,Brune, Harald American Physical Society 2017 Physical Review B Vol.96 No.22
<P>We report x-ray absorption spectroscopy and x-ray magnetic circular dichroism measurements as well as multiplet calculations for Dy, Ho, Er, and Tm atoms adsorbed on Pt(111), Cu(111), Ag(100), and Ag(111). In the gas phase, all four elements are divalent and we label their 4f occupancy as 4f(n). Upon surface adsorption, and depending on the substrate, the atoms either remain in that state or become trivalent with 4f(n-1) configuration. The trivalent state is realized when the sum of the atomic correction energies (4f -> 5d promotion energy E-fd + intershell coupling energy delta E-c) is low and the surface binding energy is large. The latter correlates with a high substrate density of states at the Fermi level. The magnetocrystalline anisotropy of trivalent RE atoms is larger than the one of divalent RE atoms. We ascribe this to the significantly smaller covalent radius of the trivalent state compared to the divalent one for a given RE element. For a given valency of the RE atom, the anisotropy is determined by the overlap between the spd states of the RE and the d states of the surface. For all investigated systems, the magnetization curves recorded at 2.5 K show absence of hysteresis indicating that magnetic relaxation is faster than about 10 s.</P>