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Song, Chanyoung,Phuengkham, Hathaichanok,Kim, Sun-Young,Lee, Min Sang,Jeong, Ji Hoon,Shin, Sung Jae,Lim, Yong Taik Dove Medical Press 2017 International journal of nanomedicine Vol.12 No.-
<P>In this study, we suggest a designer vaccine adjuvant that can mimic the drainage of pathogens into lymph nodes and activate innate immune response in lymph nodes. By the amination of multivalent carboxyl groups in poly-(γ-glutamic acid) (γ-PGA) nanomicelles, the size was reduced for rapid entry into lymphatic vessels, and the immunologically inert nanomicelles were turned into potential activators of inflammasomes. Aminated γ-PGA nanomicelles (aPNMs) induced NLRP3 inflammasome activation and the subsequent release of proinflammatory IL-1β. The NLRP3-dependent inflammasome induction mechanism was confirmed through enzyme (cathepsin B and caspase-1) inhibitors and NLRP3 knockout mice model. After the aPNMs were combined with a clinically evaluated TLR3 agonist, polyinosinic–polycytidylic acid sodium salt (aPNM-IC), they triggered multiple arms of the innate immune response, including the secretion of pro-inflammatory cytokines by both inflammasomes and an inflammasome-independent pathway and the included type I interferons.</P>
박세현,김현지,Hathaichanok Phuengkham,송찬영,임용택 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Regression of malignant tumors after post-surgical removement remains a clinical obstacle. Immune checkpoint blockade (ICB) implementation to overcome this obstacle by eliciting durable antitumor responses still holds limitation of low efficiency, which is due to fortified pro-tumoral environment after surgery. Here a promising platform, designer scaffold loaded with immune nanoconverters encapsulated with resiquimod (iNCVs (R848)) and doxorubicin, is introduced to polarize the immunosuppressing cells such as tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) to antigen-presenting cells (APCs), and simultaneously ameliorating antitumor response with low systemic toxicity, forming immunogenic TME. Along with TME modulation, duration of memory T cells specific to neoantigen prevents tumor recurrence and metastasis. Introduction of the spatiotemporal modulating designer scaffolds suggests immunogenic therapy that overcomes current limitations.