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Peter J Bush,Seyed Mehdian People&Global Business Association 2014 Global Business and Finance Review Vol.19 No.1
This article examines the Monday effect in the Dow Jones Industrial Average (DJIA) and each of its component stocks for the periods of 1962 to 1982, 2003 to 2008, and 2009 to 2012. We extend our investigation over multiple time periods to explore whether individual component securities behave in the same way as the broader index to which they are linked over time. The results provide evidence to support the presence of the Monday effect in the DJIA and its component stocks during the early period of 1962 to 1982 while no statistically significant Monday effect is found in the latter periods of 2003 to 2008 and 2009 to 2012. These findings suggest that a transformation has occurred in U.S. equity markets such that the Monday effect has reduced or disappeared in both the market-wide index and its component stocks. We conclude that this transformation is perhaps due to the faster speed of dissemination of information domestically or globally; consequently, no trading rule that is based on daily anomalies can be exploited to generate an abnormal return.
Peter J. Mitchell,Bernard Yan,Leonid Churilov,Richard J. Dowling,Steven Bush,Thang Nguyen,Bruce C.V. Campbell,Geoffrey A. Donnan,Zhongrong Miao,Stephen M, Davis 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.1
Background and Purpose The benefit regarding co-treatment with intravenous (IV) thrombolysis before mechanical thrombectomy in acute ischemic stroke with large vessel occlusion remains unclear. To test the hypothesis that clinical outcome of ischemic stroke patients with intracranial internal carotid artery, middle cerebral artery or basilar artery occlusion treated with direct endovascular thrombectomy within 4.5 hours will be non-inferior compared with that of standard bridging IV thrombolysis followed by endovascular thrombectomy. Methods To randomize 780 patients 1:1 to direct thrombectomy or bridging IV thrombolysis with thrombectomy. An international-multicenter prospective randomized open label blinded endpoint trial (PROBE) (ClincalTrials.gov identifier: NCT03494920). Results Primary endpoint is functional independence defined as modified Rankin Scale (mRS) 0–2 or return to baseline at 90 days. Secondary end points include ordinal mRS analysis, good angiographic reperfusion (modified Thrombolysis in Cerebral Infarction score [mTICI] 2b–3), safety endpoints include symptomatic intracerebral hemorrhage and death. Conclusions DIRECT-SAFE will provide unique information regarding the impact of direct thrombectomy in patients with large vessel occlusion, including patients with basilar artery occlusion, with comparison across different ethnic groups.