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        Speed Optimization in Automated Microinjection of Zebrafish Embryos

        Peter C.Y. Chen,Shengfeng Zhou,Zhe Lu,Joo-Hoo Nam,Hong Luo,RuowenGe,Chong-Jin Ong,Wei Lin 제어·로봇·시스템학회 2015 International Journal of Control, Automation, and Vol.13 No.5

        In this paper we formulate an optimization problem in the design of a speed trajectory for the motion of the micropipette during automated microinjection of zebrafish embryos. The objective of this optimization problem is to minimize the deformation sustained by the zebrafish embryo. We subsequently propose a solution to this optimization problem by first constructing a viscoelastic model of the zebrafish embryo, and then synthesizing an optimal speed trajectory based on a class of polynomials. Furthermore, we present results of numerical simulation and experiments that demonstrate the effectiveness of the proposed solution. The statistically meaningful experimental data (generated using a large sample of zebrafish embryos) provide direct evidence on the advantage of such speed optimization in microinjection.

      • Stimuli-Induced Equilibrium Point: A Psychological Field Theory Application in Ramp Merging Systems

        Kendrick Amezquita S.,Peter C. Y. Chen,Weihai Chen,Zheng Zhao 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10

        Based on the psychological field theory, the stimuli-induced equilibrium point (SIEP) model is formulated to characterize the interaction of a driver between two vehicles (leader and follower) in a three-vehicle platooning configuration. Considering the intensity of the stimuli that act upon a driver between these vehicles, the point at which the stimuli resultant becomes zero (i.e. the equilibrium point) is obtained. Consequently, the location of such a point within the leader-follower gap changes continuously according to the speed of the middle vehicle and the current traffic scenario. This methodology enables the systematic computation of speed and position references for automatic ramp merging systems. Such stimuli-induced equilibrium point has shown to improve the performance of existing merging control schemes while increasing safety conditions by providing enough reaction time for drivers to avoid and eventual collision.

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        Optimization of a Fluid Distribution Manifold

        Heng Wang,Samuel D. Marshall,Rerngchai Arayanarakool,Lakshmi Balasubramaniam,Xin Jin,Poh Seng Lee,Peter C. Y. Chen 한국유체기계학회 2018 International journal of fluid machinery and syste Vol.11 No.3

        This paper presents two optimized designs of a commonly-used fluid distribution manifold having one entrance and six exits. Numerical simulations were carried out to optimize the dimensions and mechanisms of these proposed designs for the sake of enhancing the uniformity of fluid distribution amongst the exits and reducing the formation of dead zones inside the manifold cavities. Particularly, to make the fluid distribution amongst exits more uniform, this study explored the relationship between entrance diameter and exit diameter. Furthermore, in order to reduce dead zone formations inside the manifold whilst still maintaining uniform fluid distribution, a conical cavity was designed. After that, blockers were designed to replace some exits, permitting a variable number of fluid distribution manifold exits, depending on the specific application. Both designs were found to be able to improve flow uniformity and dead zone reduction compared to the original commonly-used fluid distribution manifold, with the central-feeding distributor performing slightly better than the lateral-feeding distributor overall. From the perspective of manufacturing, each of these two fluid manifolds was made of two pieces with glue and rubber O ring used respectively as the bond between separate pieces. Preliminary experiments with these devices suggest similar results to those from the numerical studies. Based on real application requirements and limitations, the different fluid manifold designs with tunable dimensions can be utilized in various mechanical or biochemical devices to distribute fluid equally amongst several parallel components.

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