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RISS 인기검색어
- 검색키워드
- 저자 : Perez-Quintero, Alvaro L. (검색결과 2 건)
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Asselin, Jo Ann E.,Lin, Jinshan,Perez-Quintero, Alvaro L.,Gentzel, Irene,Majerczak, Doris,Opiyo, Stephen O.,Zhao, Wanying,Paek, Seung-Mann,Kim, Min Gab,Coplin, David L.,Blakeslee, Joshua J.,Mackey, Da American Society of Plant Biologists 2015 Plant Physiology Vol.167 No.3
<P><I>The virulence activity of an effector protein belonging to the widely conserved AvrE family is linked to its ability to cause system-wide reprogramming of phenylpropanoid metabolism in susceptible maize seedlings.</I></P><P>AvrE family type III effector proteins share the ability to suppress host defenses, induce disease-associated cell death, and promote bacterial growth. However, despite widespread contributions to numerous bacterial diseases in agriculturally important plants, the mode of action of these effectors remains largely unknown. WtsE is an AvrE family member required for the ability of <I>Pantoea stewartii</I> ssp. <I>stewartii</I> (<I>Pnss</I>) to proliferate efficiently and cause wilt and leaf blight symptoms in maize (<I>Zea mays</I>) plants. Notably, when WtsE is delivered by a heterologous system into the leaf cells of susceptible maize seedlings, it alone produces water-soaked disease symptoms reminiscent of those produced by <I>Pnss</I>. Thus, WtsE is a pathogenicity and virulence factor in maize, and an <I>Escherichia coli</I> heterologous delivery system can be used to study the activity of WtsE in isolation from other factors produced by <I>Pnss</I>. Transcriptional profiling of maize revealed the effects of WtsE, including induction of genes involved in secondary metabolism and suppression of genes involved in photosynthesis. Targeted metabolite quantification revealed that WtsE perturbs maize metabolism, including the induction of coumaroyl tyramine. The ability of mutant WtsE derivatives to elicit transcriptional and metabolic changes in susceptible maize seedlings correlated with their ability to promote disease. Furthermore, chemical inhibitors that block metabolic flux into the phenylpropanoid pathways targeted by WtsE also disrupted the pathogenicity and virulence activity of WtsE. While numerous metabolites produced downstream of the shikimate pathway are known to promote plant defense, our results indicate that misregulated induction of phenylpropanoid metabolism also can be used to promote pathogen virulence.</P>
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Blanca Patricia Lazalde-Ramos,Ana Lourdes Zamora-Perez,Ayme´e Ileana Ortega-Guerrero,Saira Zulema Quintero-Fraire,Omar Palacios-Lara,Sol Marı´a Quirarte-Baez,Carlos Galaviz-Hernandez,Martha Sosa-Macıa 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.10
Genomic instability is associated with increased oxidative stress in patients with human immunodeficiency virus (HIV). The aim of this study was to determine the effect of intake of methanolic and aqueous extracts of Rosmarinus officinalis on genomic instability in HIV patients. We studied 67 HIV patients under pharmacological treatment with ATRIPLA who were divided into three groups: group 1, patients under ATRIPLA antiretroviral therapy; group 2, patients with ATRIPLA and rosemary aqueous extract (4 g/L per day); and group 3, patients with ATRIPLA and rosemary methanolic extract (400 mg/day). The genomic instability was evaluated through the buccal micronucleus cytome assay. Oral epithelial cells were taken at the beginning and 1 and 4 months later. The groups that received the pharmacological therapy with ATRIPLA and the complementary therapy with R. officinalis extracts showed a decrease in the number of cells with micronuclei and nuclear abnormalities compared with the group that only received ATRIPLA. The complementary therapy with R. officinalis decreased the genomic instability in HIV patients.
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