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RISS 인기검색어
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- 저자 : Paul Tu (검색결과 2 건)
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Syzygium aromaticum L. (Clove) Extract Regulates Energy Metabolism in Myocytes
Zheng Tu,Tijuana Moss-Pierce,Paul Ford,T. Alan Jiang 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.9
The prevalence of metabolic syndrome and type 2 diabetes is increasing worldwide. Herbs and spices have been used for the treatment of diabetes for centuries in folk medicine. Syzygium aromaticum L. (Clove) extracts (SE) have been shown to perform comparably to insulin by significantly reducing blood glucose levels in animal models; however, the mechanisms are not well understood. We investigated the effects of clove on metabolism in C2C12 myocytes and demonstrated that SE significantly increases glucose consumption. The phosphorylation of AMP-activated protein kinase (AMPK), as well as its substrate, acetyl-CoA carboxylase (ACC) was increased by SE treatment. SE also transcriptionally regulates genes involved in metabolism, including sirtuin 1 (SIRT1) and PPARc coactivator 1a (PGC1a). Nicotinamide, an SIRT1 inhibitor, diminished SE’s effects on glucose consumption. Furthermore, treatment with SE dose-dependently increases muscle glycolysis and mitochondrial spare respiratory capacity. Overall, our study suggests that SE has the potential to increase muscle glycolysis and mitochondria function by activating both AMPK and SIRT1 pathways.
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Hong Zhang,Lei Shi,Xuhui Liu,Xianshu Leng,Ding Feng,Paul Tu 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.12
Wellbore trajectory control tool is a sort of point-the-bit drilling tool to achieve the steering function while drilling. In complex conditions, the spindle bears the acting force of the bit pressure, the torque, the force of biasing mechanism and so on. So the force is very complex. Basing on the early research of our group, the further research of spindle deflecting reliability of prototype has been carried out. Based on the contact analysis between the tool spindle and the inner eccentric ring, the variation law of contact stress between the inner ring of the eccentric mechanism and the spindle is studied. Based on Palmgren-Miner and the fatigue life experiment of the spindle material, the cumulative damage calculation model of the spindle is established, and the fatigue life of spindle is solved. The result shows that the deflecting reliability of the spindle can be guaranteed.
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