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Anthocyanin-Rich Blackcurrant Extract Attenuates Ovariectomy-Induced Bone Loss in Mice
Xi Zheng,Sewhan Mun,이상길,Terrence M. Vance,Patrice Hubert,Sung I. Koo,Sun-Kyeong Lee,Ock K. Chun 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.4
Although several animal and cell studies have indicated that blackcurrant anthocyanins exert antioxidative andanti-inflammatory properties, which could potentially improve bone mass, the effect of blackcurrant on bone health has notbeen reported yet. Thus, this study was aimed to evaluate the effect of blackcurrant anthocyanins on bone mass in an estrogendeficiency mouse model. Fourteen-week-old C57BL/6J mice (n = 54) were ovariectomized or sham operated. The ovariectomizedmice were divided into two groups, basal diet (OVX) or basal diet with 1% anthocyanin-rich blackcurrant extract(OVX+BC), and sacrificed at 4, 8, and 12 weeks. Femoral bone mineral density (BMD) and trabecular bone volume by dualenergyX-ray absorptiometry and micro-computed tomography, respectively, and serum bone markers were measured. Ovariectomy significantly reduced BMD and trabecular bone volume at all time points (P < .05). Blackcurrant supplementationattenuated ovariectomy-induced bone loss measured by BMD and trabecular bone volume at 8 weeks (P = .055 andP = .057) and the effect was more pronounced at 12 weeks (P = .053 and P < .05). Ovariectomy and blackcurrant treatment didnot alter serum biomarkers of bone formation and resorption. Bone marrow cells extracted from OVX mice significantlyinduced osteoclast-like (OCL) cell formation compared with cells from sham controls (P < .05). Blackcurrant treatmentdecreased the number of TRAP(+) OCL compared with OVX mice at 8 and 12 weeks (P < .05). Furthermore, blackcurrantsupplementation reduced bone resorption activity when measured by resorption pit assay, compared with OVX group(P < .05). These results demonstrate that blackcurrant may be effective in mitigating osteoclast-induced postmenopausalbone loss.