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Thiagarajan Madheswaran,Rengarajan Baskaran,Pasupathi Sundaramoorthy,유봉규 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4
The objective of this study is to enhance skinpermeation of finasteride and dutasteride for the treatmentof androgenetic alopecia using surface-modified liquidcrystalline nanoparticle (sm-LCN) dispersion. LCNentrapped with the drugs was prepared by using monooleinas a liquid crystal former, and surface modification wasperformed by treatment of the LCN dispersion with samevolume of 1 % v/v acetic acid solution containing chitosan. Physicochemical properties of the LCN’s were studied withregard to particle size, polydispersity index, zeta potential,and release of the drugs. Skin permeation of drugsentrapped into the LCN and sm-LCN was investigated withporcine abdominal skin using Franz diffusion cell. Cytotoxicityof the LCN’s was also studied using human skinkeratinocytes. The particle size and zeta potential of theLCN were 197.9 ± 2.5 nm and -20.2 ± 1.9 mV, respectively,and sm-LCN showed slightly bigger size and positivezeta potential due to the presence of thin coating on thesurface of the nanoparticles. Compared to LCN, sm-LCNresulted in significantly enhanced skin permeation of thedrugs whereas in vitro release was significantly reduced. Cell viability as a measure of cytotoxicity was above 80 %up to 20 lg/ml concentration of both LCN and sm-LCN. Inconclusion, sm-LCN may provide a strategy to maximizetherapeutic efficacy minimizing unwanted systemic sideeffects associated with the use of the drugs for the treatmentof androgenetic alopecia.
A novel autophagy inducer, AS777, ameliorates liver fibrosis via suppressing liver inflammation
Seungho Choi,Min Woo Kim,Pasupathi Sundaramoorthy,Hyun-jin Jung,Ju-Hee Kang,Kwang Won Jeong,Hwan Mook Kim,Gyoonhee Han,Jung Ju Kim,Seong Won Song,Hye Jeong Shin,Seung Hyun Oh 한국실험동물학회 2019 한국실험동물학회 학술발표대회 논문집 Vol.2019 No.1