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        Neutrophil to Lymphocyte Ratio in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy

        Alime Gunes,Musa Yigit,Levent Tok,Ozlem Tok 대한안과학회 2017 Korean Journal of Ophthalmology Vol.31 No.2

        Purpose: To evaluate the neutrophil to lymphocyte ratio (NLR) in patients with nonarteritic anterior ischemic opticneuropathy (NAION). Methods: We investigated 112 subjects comprising 56 patients with NAION and 56 healthy controls at SüleymanDemirel University. Complete blood count, demographic, and clinic data from NAION patients were evaluatedin this study. The NLR was calculated in all individuals and compared between the patient and controlgroups. Cut-off values were also determined. Then, the relationship between NLR and visual outcomes wasinvestigated. Results: The cut-off value for NLR was 1.64. NLR values were significantly higher in NAION patients than inhealthy subjects (p < 0.001) and were directly correlated with erythrocyte sedimentation rate levels (r = 0.263,p = 0.006). Also, the NLR value was associated with visual outcomes. Receiver operator characteristic curveanalysis revealed a 0.63 area under the curve (confidence interval, 53.7% to 74.1%), 85% sensitivity and 41%specificity at the cut-off NLR value. Conclusions: The NLR may be a biomarker with good sensitivity that is quick, cost effective and easily detectedin serum. It can be used in clinical practice to predict a NAION patient’s prognosis in terms of visual outcomes.

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        Is Retinal Nerve Fiber Layer Thickness Change Related to Headache Lateralization in Migraine?

        Alime Gunes,Seden Demirci,Levent Tok,Ozlem Tok,Serpil Demirci,,leyman Kutluhan 대한안과학회 2016 Korean Journal of Ophthalmology Vol.30 No.2

        Purpose: To evaluate retinal nerve fiber layer (RNFL) thickness in migraine patients with unilateral headache. Methods: A total of 58 patients diagnosed with migraine headache consistently occurring on the same side and 58 age- and sex-matched healthy subjects were evaluated in this cross-sectional study. RNFL thickness was measured using spectral-domain optical coherence tomography, and the side with the headache was compared with the contralateral side as well as with the results of healthy subjects. Results: The mean patient age was 33.05 ± 8.83 years, and that of the healthy subjects was 31.44 ± 8.64 years (p = 0.32). The mean duration of disease was 10.29 ± 9.03 years. The average and nasal RNFL thicknesses were significantly thinner on the side of headache and on the contralateral side compared to control eyes (p< 0.05, for all). Thinning was higher on the side of the headache compared to the contralateral side; however, this difference was not statistically significant. Conclusions: The RNFL thicknesses were thinner on the side of the headache compared to the contralateral side in the migraine patients with unilateral headache, but this difference was not statistically significant.

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