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- 저자 : Osmani, Asif Husain (검색결과 3 건)
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Osmani, Asif Husain,Ansari, Tayyaba Zehra,Masood, Nehal,Ahmed, Bilal Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Introduction: Febrile neutropenia is a relatively frequent event in cancer patients treated with chemotherapy and improvement in absolute neutrophil count (ANC) has been linked directly to improved outcome. Evaluation of granulocyte colony stimulating factors (GCSFs) for treatment has shown reduced incidences of episodes of prolonged neutropenia and protracted hospitalization. To determine absolute neutrophil counts with GCSF in febrile neutropenic cancer patients admitted to a tertiary care centre and to co-relate the improvement in ANC with mortality and hospital discharge. Methods: A prospective cross sectional study was carried at an oncology ward at Aga Khan University hospital from January 2010 to June 2011. All adult patients who were admitted and treated with GCSF for chemotherapy induced febrile neutropenia were included. Multivariable regression was conducted to identify the factors related with poor outcomes. Results: A total of 131 patients with febrile neutropenia were identified with mean age of 43.2 (18-85) years, 79 (60%) being ${\leq}50$. Seventy-five (57%) had solid tumors and 56 (43%) hematological malignancies, including lymphoma. Fifty seven (43.5%) had an ANC less 100 cells/$mm^3$, 34 (26%) one between 100-300 cells/$mm^3$ and 40 (31%) an ANC greater than 300 cells/$mm^3$. Thirty (23%) patients showed ANC recovery in 1-3 days, and 74(56%) within 4-7 days. Thirteen (10%) patients showed no recovery. The overall mortality was 18 (13.7%) patients. The mean time for ANC recovery seen in hematological malignancies was 6.34 days whereas for solid tumors it was 4.88 days. Patients with ANC <100 cells/$mm^3$ were more likely to die than patients with ANC >300 cells/$mm^3$ by a factor of 4.3. Similarly patients >50 years of age were 2.7 times more likely to die than younger patients. Conclusion: Our study demonstrated that use of GCSF, in addition to intravenous antibiotics, in treatment of patients with chemotherapy induced febrile neutropenia accelerates neutrophil recovery, and shortens antibiotic therapy and hospitalization. We propose to risk classify the patients at the time of admission to evaluate the cost effectiveness of this approach in a resource constrained setup.
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B. V. Feujofack Kemda,N. Barka,M. Jahazi,D. Osmani 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.5
In recent years, the usage of dual phase (DP) steels, transformation induced plasticity (TRIP) steels and boron steels in someauto body parts has become a necessity because of their strength and lightweight. Resistance spot welding (RSW) being aprocess were steel is heated and cooled in a very short period of time, the resulting weld nugget is generally fully martensitic,especially in the case of DP, TRIP and boron steels but that also holds for plain carbon steels as AISI 1010 grade whichis extensively used in auto body inner parts. Martensite in is turn must be avoided as much as possible when welding steelbecause it is the principal source of brittleness. Thus, this work aims in finding a mean to reduce martensite fraction andincrease phase diversity in weld nugget. The prediction of phase transformation during RSW has been done. Simulationshave been performed for 2 mm AISI 1010 sheets and results show that the application of post weld heat treatment leads tothe reduction of martensite fraction, and formation of ferrite and bainite in the nugget. Welding experiments have been donein parallel and experimental weld nugget geometry is in good agreement with simulation results.
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B. V. Feujofack Kemda,N. Barka,M. Jahazi,D. Osmani 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.2
Industry is constantly moving towards an increasing of production speed while minimizing production costs. This paperpresents an efficient method for minimizing production times and energies through optimization of process parameters inresistance spot welding (RSW). Two grades of steel were used in this study, ASTM A36 steel and A653 hot dipped galvanizedsteel. Welding was done in overlap configuration, grade for grade, while following complete factorial plans. Micrographicanalysis revealed welds microstructure while micro-indentation hardness tests enabled to establish hardness profiles alongweld nuggets. Tensile-shear tests have been carried out in order to quantify the mechanical strength of welds. Analysis ofvariance showed that welding current is the most significant parameter and contributes for about 70% to welds mechanicalstrength. The ratio of hardness in the fusion zone to nugget surface area was found to be correlated with the failure modeof welded specimens. On that basis, a multi-objective optimization of the process parameters, through the non-dominatedsorting genetic algorithm was performed. This optimization resulted in a reduction of current, electrode pressing force andwelding time of 10.58%, 13.59% and 32.61% respectively. Optimized parameters were then assessed trough tensile-sheartesting of welded specimens, all specimens passed the validation tests by experiencing failure in the base metal.
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