RISS 검색 - 국내학술지논문

무료
기관 내 무료
유료

내보내기
내책장담기
한글로보기

정확도순

내림차순

내림차순

10개씩 출력

1
Mondia whitei, an African Spice Inhibits Mitochondrial Permeability Transition in Rat Liver

Olanlokun Oludele,Bakare Idris,Ofoegbu Benard,Uleh Pius,Olorunsogo Olufunso 한국식품영양과학회 2018 Preventive Nutrition and Food Science Vol.23 No.3
- 원문보기
Mondia whitei is an African traditional spice with aphrodisiac properties. Inhibition of mitochondrial permeability transition (mPT) pore is an important cytoprotective process essential for cell survival. In this study, the effects of methanol extract (ME), dichloromethane (DCMF), ethyl acetate (EF), and methanol fractions (MF) of Mondia whitei on mPT, mitochondrial ATPase, lipid peroxidation, testosterone hormone (TH), luteinizing hormone (LH), and follicle stimulating hormone (FSH) were investigated; sperm analyses were also carried out. Male experimental rats were treated intraperitoneally with 25, 50, and 100 mg/kg bw of ME, DCMF, EF, and MF of Mondia whitei for two weeks. The positive and the negative controls received sildenafil citrate and the vehicle, respectively. The results showed that mPT was inhibited by MF at the highest dose. The ME, DCMF, and MF did not enhance ATPase activity. The levels of TH, FSH, and LH varied linearly with the drug dose only in EF. Malondialdehyde levels in the treated groups were significantly higher than the normal control. There were no significant defects in sperm produced by the animals in all the treated groups relative to the control. This study showed that the extract and fractions of Mondia whitei have cytoprotective effects and may prevent mitochondrial-mediated cell death.
2
Modelling the Mont Terri HE-D experiment for the Thermal–Hydraulic–Mechanical response of a bedded argillaceous formation to heating

Garitte, B.,Nguyen, T. S.,Barnichon, J. D.,Graupner, B. J.,Lee, C.,Maekawa, K.,Manepally, C.,Ofoegbu, G.,Dasgupta, B.,Fedors, R.,Pan, P. Z.,Feng, X. T.,Rutqvist, J.,Chen, F.,Birkholzer, Jens,Wang, Q. Springer 2017 Environmental Earth Sciences Vol.76 No.9
- 원문보기
<P>Coupled thermal-hydrological-mechanical (THM) processes in the near field of deep geological repositories can influence several safety features of the engineered and geological barriers. Among those features are: the possibility of damage in the host rock, the time for re-saturation of the bentonite, and the perturbations in the hydraulic regime in both the rock and engineered seals. Within the international cooperative code-validation project DECOVALEX-2015, eight research teams developed models to simulate an in situ heater experiment, called HE-D, in Opalinus Clay at the Mont Terri Underground Research Laboratory in Switzerland. The models were developed from the theory of poroelasticity order to simulate the coupled THM processes that prevailed during the experiment and thereby to characterize the in situ THM properties of Opalinus Clay. The modelling results for the evolution of temperature, pore water pressure, and deformation at different points are consistent among the research teams and compare favourably with the experimental data in terms of trends and absolute values. The models were able to reproduce the main physical processes of the experiment. In particular, most teams simulated temperature and thermally induced pore water pressure well, including spatial variations caused by inherent anisotropy due to bedding.</P>