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RISS 인기검색어
- 검색키워드
- 저자 : Nemany Hanafy (검색결과 2 건)
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Ahmed Magdy,Emad Sadaka,Nemany Hanafy,Mohammed A. El‑Magd,Nasr Allahloubi,Maged El Kemary 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3
Background Silver nanoparticles (AgNPs) have anti-cancer effects with fewer side effects than standard chemotherapeutic agents, however, they exert oxidative stress-based adverse effects on normal cells and so their applications have raised concern about possible health and environmental risks. Objective We evaluated whether green tea extract (GTE), which contains potent antioxidants, could ameliorate AgNPs geno-, cyto-, and histotoxicities without decreasing their therapeutic potential against Ehrlich ascetic carcinoma (EAC). Results GTE enhanced the anti-cancer effect of AgNPs against EAC cells and ameliorated the genotoxic effect of AgNPs as indicated by lowering chromosomal aberrations and micronucleus frequencies. Additionally, GTE relieved most of degenerative histological changes induced by AgNPs. GTE restored the increased MDA and the decreased SOD, GPx and CAT serum levels induced by AgNPs to levels comparable to normal. The pre-treatment with GTE and AgNPs showed better improvement than the post-treatment strategy. Conclusions GTE can not only ameliorate AgNPs-induced adverse effects but also improve their anti-cancer effect against EAC. So, it could be useful in the treatment of liver dysfunction associated with AgNPs.
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Hollow Spherical Curcumin Nanomicelles CUR@PLA@PF127: A New Trial on Breast Cancer Cells
Fatma S. El-Banna,Nemany A. N. Hanafy,Magdy E. Mahfouz,Maged El Kemary 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.5
Curcumin (CUR) nanomicelles were developed by solvent-evaporation method using Poly (lactic acid) (PLA) for the first time with Pluronic F127 (PF127) to produce CUR@PLA@PF127 nanomicelles. The X-ray diffraction (XRD) spectra confirmed the encapsulation of CUR into the produced nanomicelles (CUR@PLA@PF127). Fourier transform infrared spectroscopy (FTIR) analysis showed the interactions of CUR with PLA and PF127. Scanning electron microscope (SEM) and transmission electron microscope (TEM) analysis showed the formation of spherical shape of CUR@PLA@PF127 with a diameter around 130-160 nm. To investigate the anticancer effect of the encapsulated CUR, the activity of CUR@PLA@PF127 nanomicelles, free CUR and blank nanomicelles (PLA@PF127) were assayed against two cell lines in-vitro, human breast adenocarcinoma cells (MCF-7) and human breast skin fibroblast cells. The cytotoxicity assay of CUR@PLA@PF127 nanomicelles, revealed an IC50 value of 159.7 ± 1.36 μg/mL for MCF-7 cells which is much lower than that observed for free CUR. This result suggests that CUR@PLA@PF127 nanomicelles increased CUR potency due to improving its water solubility, resulting in longer release profile, and increasing antiproliferative effect on breast cancer cells (MCF-7). We anticipate that CUR@PLA@PF127 in drug delivery, improving drugs design and that the developed nanomicelles will be regarded one of the most promising nanocarriers for the treatment of breast cancer, and opening the door to future applications in cancer therapies.
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