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- 저자 : Nathan Davies (검색결과 4 건)
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Bill, Nathan L.,Lim, Jong Min,Davis, Christina M.,Bä,hring, Steffen,Jeppesen, Jan O.,Kim, Dongho,Sessler, Jonathan L. The Royal Society of Chemistry 2014 Chemical communications Vol.50 No.51
<P>A π-extended tetrathiafulvalene-boradiazaindacene chimera, ex-TTF-BODIPY, has been prepared. The resulting system undergoes sequential one-electron oxidations, allowing access to both the mono-oxidized radical cationic and dicationic states. Additionally, ex-TTF-BODIPY displays electrochromic and electrofluorochromic behaviour in the near-IR portion of the electromagnetic spectrum and functions as a redox switched “on–off–on” emissive system.</P> <P>Graphic Abstract</P><P>Ex-TTF-BODIPY functions as a near-IR electrochromic and electrofluorochromic switch, displaying redox controlled “on–off–on” emission features. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cc02567a'> </P>
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Bill, Nathan L.,Ishida, Masatoshi,Bä,hring, Steffen,Lim, Jong Min,Lee, Sangsu,Davis, Christina M.,Lynch, Vincent M.,Nielsen, Kent A.,Jeppesen, Jan O.,Ohkubo, Kei,Fukuzumi, Shunichi,Kim, Dongho,S American Chemical Society 2013 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.135 No.29
<P>A new class of redox-active free base and metalloporphyrins fused with the 1,3-dithiol-2-ylidene subunits present in tetrathiafulvalene, termed MTTFP (M = H<SUB>2</SUB>, Cu, Ni, Zn), have been prepared and characterized. The strong electron-donating properties of MTTFP were probed by electrochemical measurement and demonstrated that oxidation potentials can be tuned by metalation of the free base form, H<SUB>2</SUB>TTFP. X-ray crystal structures of H<SUB>2</SUB>TTFP, ZnTTFP, and CuTTFP revealed that a severe saddle-shape distortion was observed with the dithiole rings bent out of the plane toward one another in the neutral form. In contrast, the structure of the two-electron oxidized species (CuTFFP<SUP>2+</SUP>) is planar, corresponding to a change from a nonaromatic to aromatic structure upon oxidation. A relatively large two-photon absorption (TPA) cross-section value of H<SUB>2</SUB>TTFP<SUP>2+</SUP> (1200 GM) was obtained for the free base compound, a value that is much higher than those typically seen for porphyrins (<100 GM). Augmented TPA values for the metal complexes were also seen. The strong electron-donating ability of ZnTTFP was further enhanced by binding of Cl<SUP>–</SUP> and Br<SUP>–</SUP> as revealed by thermal electron-transfer between ZnTTFP and Li<SUP>+</SUP>-encapsulated C<SUB>60</SUB> (Li<SUP>+</SUP>@C<SUB>60</SUB>) in benzonitrile, which was “switched on” by the addition of either Cl<SUP>–</SUP> or Br<SUP>–</SUP> (as the tetrabutylammonium salts). The X-ray crystal structure of Cl<SUP>–</SUP>-bound ZnTTFP was determined and provided support for the strong binding between the Cl<SUP>–</SUP> anion and the Zn<SUP>2+</SUP> cation present in ZnTTFP.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2013/jacsat.2013.135.issue-29/ja404830y/production/images/medium/ja-2013-04830y_0015.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja404830y'>ACS Electronic Supporting Info</A></P>
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Daphne Sze Ki Cheung,Patrick Pui Kin Kor,Cindy Jones,Nathan Davies,Wendy Moyle,Wai Tong Chien,Annie Lai King Yip,Suzanne Chambers,Clare Tsz Kiu Yu,Claudia K.Y. Lai 한국간호과학회 2020 Asian Nursing Research Vol.14 No.4
Purpose: The aim of this study was to investigate the feasibility and preliminary efficacy of a modifiedmindfulness-based stress reduction (MBSR) program and mindfulness-based cognitive therapy (MBCT)program for reducing the stress, depressive symptoms, and subjective burden of family caregivers ofpeople with dementia (PWD). Methods: A prospective, parallel-group, randomized controlled trial design was adopted. Fifty-sevenparticipants were recruited from the community and randomized into either the modified MBSRgroup (n ¼ 27) or modified MBCT group (n ¼ 26), receiving seven face-to-face intervention sessions formore than 16 weeks. Various psychological outcomes were measured at baseline (T0), immediately afterintervention (T1), and at the 3-month follow-up (T2). Results: Both interventions were found to be feasible in view of the high attendance (more than 70.0%)and low attrition (3.8%) rates. The mixed analysis of variance (ANOVA) results showed positive withingroupeffects on perceived stress (p ¼ .030, Cohen's d ¼ 0.54), depressive symptoms (p ¼ .002,Cohen's d ¼ 0.77), and subjective caregiver burden (p < .001, Cohen's d ¼ 1.12) in both interventionsacross the time points, whereas the modified MBCT had a larger effect on stress reduction, comparedwith the modified MBSR (p ¼ .019). Conclusion: Both the modified MBSR and MBCT are acceptable to family caregivers of PWD. Their preliminaryeffects were improvements in stress, depressive symptoms, and subjective burden. The modifiedMBCT may be more suitable for caregivers of PWD than the MBSR. A future clinical trial is needed toconfirm their effectiveness in improving the psychological well-being of caregivers of PWD.
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Effects of Neoadjuvant Chemotherapy on Rates of Depression in Muscle Invasive Bladder Cancer
Matthew DeSanto,Frank H. Annie,Stacie Deslich,Thomas Cato,Clayton Davis,Nathan Hale 대한비뇨기종양학회 2024 Journal of Urologic Oncology Vol.22 No.2
Purpose: The objective of this large retrospective cohort study is to better understand the relationship of bladder cancer and depression incidence, specifically relating to the incorporation of neoadjuvant chemotherapy (NCT) in treatment plans. Materials and Methods: This is a large retrospective cohort study utilizing a formulated dataset from the TriNetX Research Network Database. ICD-10 (International Statistical Classification of Diseases, 10th revision) codes related to bladder cancer and depression diagnoses and treatments were implemented to identify patients of interest. Propensity score matching was implemented for various demographic factors and comorbidities. The patient population was limited to stage T2 bladder cancer, and NCT was defined as receival within 90 days prior to cystectomy (CYS). The primary outcome was denoted as depressive episode diagnosis within 3 months of CYS. Secondary outcomes of hospitalizations, mortality, and suicide attempts within 3 months of CYS were analyzed. Results: In total, 4,630 patients were included after propensity score matching, yielding 2,315 patients per group. All patients had T2 disease and underwent CYS. In the NCT cohort, 243 patients (10.5%) acquired a diagnosis of depression within 3 months from CYS compared to 144 patients (6.2%) who received no NCT (95% confidence interval [CI], 0.027– 0.059; p<0.001). Odds ratio was 1.768 (95% CI, 1.426–2.192) when comparing cohorts with and without NCT. There was no statistical difference in mortality (95% CI, -0.012 to 0.014; p=0.844) or inpatient hospitalizations (95% CI, -0.046 to 0.009; p=0.191) within 3 months. There was a statistically significant increase in suicide attempts in the NCT group within 3 months (95% CI, 0.002–0.007; p=0.002). Conclusions: Bladder cancer can induce significant patient morbidity with ensuing depression. Our retrospective cohort study demonstrates NCT correlates to increased incidence of depression as well as suicidal attempts. Assiduous attention needs to be directed towards mental health counseling and treatment for oncologic patients.
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