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RISS 인기검색어
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- 저자 : Natalie Tran (검색결과 2 건)
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Matthew H. Anstey,Rashmi Rauniyar,Ethan Fitzclarence,Natalie Tran,Emma Osnain,Bianca Mammana,Angela Jacques,Robert N Palmer,Andrew Chapman,Bradley Wibrow 대한중환자의학회 2022 Acute and Critical Care Vol.37 No.3
Background:To explore the feasibility, safety, and potential benefits of administration of the anabolic steroid nandrolone to patients in the recovery phase from critical illness weakness.Methods: In this phase II, double blind, randomized, controlled trial, adult critically ill patients admitted to one of two tertiary Intensive Care Units in Western Australia for longer than 7 days with significant weakness were enrolled. Patients received nandrolone (200 mg males, 100 mg females) intramuscularly or placebo weekly for up to 3 weeks in addition to standard care. The primary outcome measures were improvement in grip strength, Medical Research Council muscle strength sum score, and functional activity level (Chelsea critical care assessment tool [CPAx]).Results: A total of 22 patients was enrolled between September 2017 and May 2019. No significant adverse events were detected. Median grip strength change was non-significantly greater in the nandrolone group (8.5 vs. 13.0, P=0.185), while hospital length of stay (36 vs. 26 days, P=0.023) and duration of mechanical ventilation (377 vs. 168, P=0.032) were lower. The discharge CPAx and intensive care unit mobility scores were higher in the nandrolone group, although there was no difference in the change in CPAx score (17.0 vs. 17.7, P=0.865). There were no changes in ultrasound-detected muscle thickness between the two groups.Conclusions: In patients with prolonged critical illness, nandrolone appears to be safe. However, a larger study, potentially combined with resistance exercise, is needed to definitively address the potential benefits of nandrolone.
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Priyanka Shiveshwarkar,Savier Vega Siurano,Mahri Kadyrova,Natalie Tran,Justyn Jaworski 한국고분자학회 2022 Macromolecular Research Vol.30 No.1
Polydiacetylene based sensors have been used for a variety of sensing applications. Here we demonstrate that diacetylene-containing amphiphiles could be spray processed to provide unique sensor coatings that may be applied to a variety of material surfaces. Utilizing an airbrushing technique, we examined processing parameters to yield spray-on sensors for detecting UV, temperature, as well as chemical/ solvent targets depending on the pendant side chain chemistry of the resulting polydiacetylene coating. We observed that the concentration, carrier solvent, and UV exposure time had a significant effect on the colorimetric response of the sprayed on coating with better responses observed at higher amphiphile concentration and shorter polymerization times. We expect this approach to generating spray-on responsive coatings will provide a widely deployable means for detection that may be customized for a variety of sensing applications.
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