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      저자 : Nasrin Shahifar (검색결과 1 건)
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        Different reference ranges affect the prevalence of osteoporosis and osteopenia in an urban adult Malaysian population

        Swan Sim Yeap,Subashini C. Thambiah,Intan Nureslyna Samsudin,Geeta Appannah,Nurunnaim Zainuddin,Safarina Mohamad-Ismuddin,Nasrin Shahifar,Salmiah Md-Said,Siti Yazmin Zahari Sham,Subapriya Suppiah,Fen 대한골다공증학회 2020 Osteoporosis and Sarcopenia Vol.6 No.4

        Objectives: To determine the prevalence of osteopenia (OPe) and osteoporosis (OP) in an urban adult population in Malaysia, and to compare the change in the prevalence when using a Caucasian compared to an Asian reference range. Methods: A cross-sectional random sample of the population aged between 45 and 90 years from the state of Selangor, Malaysia, was invited to attend a bone health check-up. Participants with diseases known to affect bone metabolism or who were on treatment for OP were excluded. Bone mineral density was measured using dual energy X-ray absorptiometry. Based on the World Health Organization definitions, the prevalence of OPe and OP was calculated using the Asian and Caucasian T-scores. Results: A total of 342 subjects (222 females, 120 males), with a mean age of 59.68 (standard deviation: 8.89) years, who fulfilled the study criteria were assessed. Based on the Asian reference range, there were 140 (40.9%) subjects with OPe and 48 (14.0%) with OP. On applying the Caucasian reference range, there were 152 (44.4%) subjects with OPe and 79 (23.1%) with OP, with significant increases in males, females, and Chinese ethnic groups. Overall, 75 (21.9%) of subjects had a change in their diagnostic status. T-scores were consistently lower when the Caucasian reference range was used. Conclusions: In a healthy urban Malaysian population, the prevalence of OP is 14.0% and OPe is 40.9%. Application of a Caucasian reference range significantly increased the number of subjects with OP and may potentially lead to over-treatment.

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