http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sasaki, Yusuke,Hamaguchi, Tetsuya,Yamada, Yasuhide,Takahashi, Naoki,Shoji, Hirokazu,Honma, Yoshitaka,Iwasa, Satoru,Okita, Natsuko,Takashima, Atsuo,Kato, Ken,Nagai, Yushi,Taniguchi, Hirokazu,Boku, Nari Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2
Background: It is well known that peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is associated with a poor prognosis. However, data on the prognostic significance of modern chemotherapy containing bevacizumab, cetuximab or panitumumab are not available. Materials and Methods: This retrospective review concerned 526 patients with metastatic CRC who were classified into two groups according to the presence or absence of PC, and were treated with systemic chemotherapy, with or without bevacizumab or anti-EGFR antibodies. The genetic background, in particular KRAS, BRAF, and PIK3CA gene mutations, and overall survival (OS) were compared between the two groups. Results: The median OS values were 23.3 and 29.1 months for PC and non-PC patients, respectively (hazard ratio [HR]=1.20; p=0.17). Among all patients, tumor location, number of metastatic sites and BRAF mutation status were significant prognostic factors, whereas the presence of PC was not. In the PC group, chemotherapy with bevacizumab resulted in a significantly longer OS than forchemotherapy without bevacizumab (HR=0.38, p<0.01), but this was not the case in the non-PC group (HR=0.80, p=0.10). Furthermore, the incidence of the BRAF V600E mutation was significantly higher in PC than in non-PC patients (27.7% versus 7.3%, p<0.01). BRAF mutations displayed a strong correlation with shorter OS in non-PC (HR=2.26), but not PC patients (HR=1.04). Conclusions: Systemic chemotherapy, especially when combined with bevacizumab, improved survival in patients with PC from CRC as well as non-PC patients. While BRAF mutation demonstrated a high frequency in PC patients, but it was not associated with prognosis.
Development of a New Tooth Profile Designed for High Efficiency P/M Internal Gear Pump Rotors
Inui Naoki,Ogata Daisuke,Sasaki Harumistu 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
We developed a new tooth profile designed for P/M internal gear pump rotors. The theoretical discharge volume of the new tooth profile internal gear rotors is more than 10% higher than that of the same size conventional rotors. Our new profile rotors can achieve a decrease in torque, and fuel-efficiency will also be improved.
Dispersion-Flocculation Behavior of Fine Lead Particles in an Organic Solvent
Tsunekawa, Masami,Sasaki, Yuta,Nakamura, Yoshiaki,Ito, Mayumi,Hiroyoshi, Naoki,Yoo, Kyoung Keun The Japan Institute of Metals 2008 Materials transactions Vol.49 No.9
<P>Methyl ethyl ketone (MEK) is a good solvent for polyvinyl chloride (PVC) and it has been proposed for use in PVC recycling. In the recycling process, fine particles of 3PbO·PbSO<SUB>4</SUB>·H<SUB>2</SUB>O, used as a thermal stabilizer in PVC products, are dispersed and not dissolved in the solvent. To establish methods for removing of 3PbO·PbSO<SUB>4</SUB>·H<SUB>2</SUB>O particles from the solvent, factors affecting the dispersion-flocculation behavior of the particles in MEK were investigated.The zeta potential and particle distribution of 3PbO·PbSO<SUB>4</SUB>·H<SUB>2</SUB>O particles in MEK solutions containing known amounts of H<SUB>2</SUB>O were measured. Above 5 vol%H<SUB>2</SUB>O in MEK solutions, the zeta potential of 3PbO·PbSO<SUB>4</SUB>·H<SUB>2</SUB>O particles approached zero and the flocculation of particles was achieved. In addition, it was found that Pb<SUP>2+</SUP> and Cl<SUP>−</SUP> affect the zeta potential of the particles. These results indicate that the dispersion-flocculation behavior of lead particles can be influenced by the concentration of H<SUB>2</SUB>O, Pb<SUP>2+</SUP>, and Cl<SUP>−</SUP> in MEK.</P>
Takafumi Mie,Takashi Sasaki,Takeshi Okamoto,Tsuyoshi Takeda,Chinatsu Mori,Yuto Yamada,Takaaki Furukawa,Akiyoshi Kasuga,Masato Matsuyama,Masato Ozaka,Naoki Sasahira 대한소화기내시경학회 2024 Clinical Endoscopy Vol.57 No.2
Background/Aims: Hepaticojejunostomy anastomotic stricture (HJAS) is a feared adverse event associated with hepatopancreatobiliary surgery. Although balloon dilation for benign HJAS during endoscopic retrograde cholangiopancreatography with balloon-assisted enteroscopy has been reported to be useful, the treatment strategy remains controversial. Therefore, we evaluated the outcomes and risk factors of recurrent stenosis after balloon dilation alone for benign HJAS. Methods: We retrospectively analyzed consecutive patients who underwent balloon-assisted enteroscopy-endoscopic retrograde cholangiopancreatography for benign HJAS at our institution between July 2014 and December 2020. Results: Forty-six patients were included, 16 of whom had recurrent HJAS after balloon dilation. The patency rates at 1 and 2 years after balloon dilation were 76.8% and 64.2%, respectively. Presence of a residual balloon notch during balloon dilation was an independent predictor of recurrence (hazard ratio, 2.80; 95% confidence interval, 1.01–7.78; p=0.048), whereas HJAS within postoperative 1 year tended to be associated with recurrence (hazard ratio, 2.43; 95% confidence interval, 0.85–6.89; p=0.096). The patency rates in patients without a residual balloon notch were 82.1% and 73.1% after 1 and 2 years, respectively. Conclusions: Balloon dilation alone may be a viable option for patients with benign HJAS without residual balloon notches on fluoroscopy.
Takeshi Okamoto,Takashi Sasaki,Tsuyoshi Takeda,Takafumi Mie,Chinatsu Mori,Takaaki Furukawa,Yuto Yamada,Akiyoshi Kasuga,Masato Matsuyama,Masato Ozaka,Naoki Sasahira 대한소화기내시경학회 2024 Clinical Endoscopy Vol.57 No.1
Background/Aims: Selective bile duct or pancreatic duct cannulation remains a significant initial hurdle in endoscopic retrograde cholangiopancreatography (ERCP) despite advances in endoscopy and accessories. This study evaluated our experience with a rotatable sphincterotome in cases of difficult cannulation. Methods: We retrospectively reviewed ERCP cases using TRUEtome, a rotatable sphincterotome, as a rescue device for cannulation at a cancer institute in Japan from October 2014 to December 2021. Results: TRUEtome was used in 88 patients. Duodenoscopes were used for 51 patients, while single-balloon enteroscopes (SBE) were used for 37 patients. TRUEtome was used for biliary and pancreatic duct cannulation (84.1%), intrahepatic bile duct selection (12.5%), and strictures of the afferent limb (3.4%). Cannulation success rates were similar in the duodenoscope and SBE groups (86.3% vs. 75.7%, p=0.213). TRUEtome was more commonly used in cases with steep cannulation angles in the duodenoscope group and in cases requiring cannulation in different directions in the SBE group. There were no significant differences in adverse events between the two groups. Conclusions: The cannulation sphincterotome was useful for difficult cannulations in both unaltered and surgically altered anatomies. It may be an option to consider before high-risk procedures such as precut and endoscopic ultrasound-guided rendezvous techniques.
Takafumi Mie,Takashi Sasaki,Ryo Kanata,Takaaki Furukawa,Tsuyoshi Takeda,Akiyoshi Kasuga,Masato Matsuyama,Masato Ozaka,Naoki Sasahira 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.5
Background/Aims: Several fine-needle biopsy (FNB) needles are available for endoscopic ultrasound (EUS)-guided tissueacquisition. However, there is disagreement on which type of needle has the best diagnostic yield. The aim of this study was tocompare the performance and safety of two commonly used EUS-FNB needles. Methods: We retrospectively analyzed consecutive patients who underwent EUS-FNB between June 2016 and March 2020 in ourhospital. Two types of needles were evaluated: a 20-gauge Menghini needle with a lateral forward bevel and a 22-gauge Franseenneedle. Rapid on-site evaluation was performed in all the cases. A multivariate analysis was performed to clarify the negativepredictive factors for obtaining a histological diagnosis. Propensity score matching was performed to compare the diagnostic yieldsof these two needles. Results: We analyzed 666 patients and 690 lesions. The overall diagnostic rate of histology alone was 88.8%, and the overall adverseevent rate was 1.5%. Transduodenal access and small lesions (≤2 cm) were identified as negative predictive factors for obtaining ahistological diagnosis. After propensity score matching, 482 lesions were analyzed. The diagnostic accuracy rates of histology in theM and F needle groups were 89.2% and 88.8%, respectively (p=1.00). Conclusions: Both the needles showed high diagnostic yield, and no significant difference in performance was observed between thetwo.
Tsuyoshi Takeda,Takashi Sasaki,Takafumi Mie,Takeshi Okamoto,Chinatsu Mori,Takaaki Furukawa,Yuto Yamada,Akiyoshi Kasuga,Masato Matsuyama,Masato Ozaka,Naoki Sasahira 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.4
Background/Aims: Digital single-operator cholangioscopy (DSOC)-guided mapping biopsy (DMB) and tube-assisted mapping biopsy(TMB) are two techniques used for preoperative evaluation of biliary tract cancer (BTC). However, data regarding the diagnostic performanceof these techniques are limited. Methods: We retrospectively examined consecutive patients with BTC who underwent either technique at our institution between2018 and 2020. We evaluated the technical success rate, adequate tissue acquisition rate, and diagnostic performance of these techniquesfor the evaluation of lateral spread of BTC. Results: A total of 54 patients were included in the study. The technical success rate of reaching the target sites was 95% for DMB and100% for TMB. The adequate tissue acquisition rate was 61% for DMB and 69% for TMB. The adequate tissue acquisition rate was low,especially for target sites beyond the secondary biliary radicles. The sensitivity of DMB alone was 39%, which improved to 65% whencombined with visual impression. Experts demonstrated a higher negative predictive value and diagnostic accuracy with respect toboth DSOC visual impression and DMB for the evaluation of lateral spread of BTC compared to trainees. Conclusions: Adequate tissue acquisition rates were similar between the two techniques. Since DMB requires expertise, TMB may bean acceptable option when DSOC is unavailable or when DSOC expertise is limited.
Wataru Yamagata,Toshio Fujisawa,Takashi Sasaki,Rei Ishibashi,Tomotaka Saito,Shuntaro Yoshida,Shizuka No,Kouta Inoue,Yousuke Nakai,Naoki Sasahira,Hiroyuki Isayama 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.5
Background/Aims: Mechanical properties (MPs) and axial and radial force (AF and RF) may influence the efficacy and complicationsof self-expandable metallic stent (SEMS) placement. We measured the MPs of various SEMSs and examined their influence on theSEMS clinical ability. Methods: We evaluated the MPs of 29 types of 10-mm SEMSs. RF was measured using a conventional measurement device. AF wasmeasured using the conventional and new methods, and the correlation between the methods was evaluated. Results: A high correlation in AFs was observed, as measured by the new and conventional manual methods. AF and RF scatterplotsdivided the SEMSs into three subgroups according to structure: hook-and-cross-type (low AF and RF), cross-type (high AF and lowRF), and laser-cut-type (intermediate AF and high RF). The hook-and-cross-type had the largest axial force zero border (>20°), followedby the laser-cut and cross types. Conclusions: MPs were related to stent structure. Hook-and-cross-type SEMSs had a low AF and high axial force zero border and wereconsidered safest because they caused minimal stress on the biliary wall. However, the increase in RF must be overcome.