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Chiappelli, Francesco,Liu, Nancy Korean Academy of Oral Biology and the UCLA Dental 1999 International Journal of Oral Biology Vol.24 No.2
Physiological processes are remarkably well conserved through evolution, and finely modulate the vast array of immune responses, which, taken together, constitute immune surveillance. The neuroendocrine system, including catecholaminergic, cholinergic and vagal innervation as well as the endogenous opioid, the pro-opiomelanocortin and other families of peptides, steroid and other hormones, play a significant role in modulating the cellular, biochemical and molecular pathways that direct and regulate immune surveillance. Immune responses control and contain the spectrum of pathologies of the oral cavity, as well as their systemic sequelae. Non-mammalian organisms exhibit physiological responses similar to those of mammals, and thus provide reliable and simple animal models for targeted research in the domain of oral biology and medicine, Fish in particular provide simple, economic and reliabel non-mammalian systems to characterize and to define neuroendocrine-immune modulatory pathways, and to test well-defined experimental manipulations for the development of novel therapeutic interventions and the refinement of existing ones.
Community Health Worker Hepatitis B Education for Cambodian American Men and Women
Taylor, Victoria Mary,Burke, Nancy Jean,Sos, Channdara,Do, Huyen Hoai,Liu, Qi,Yasui, Yutaka Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8
Background: Cambodian Americans have high rates of chronic hepatitis B virus (HBV) infection and liver cancer. There is very limited information about the utility of community health worker (CHW) approaches to cancer education for Asian American men. We have previously reported our positive findings from a trial of CHW education about HBV for Cambodian Americans who had never been tested for HBV. This report describes similarities and differences between the outcomes of our CHW HBV educational intervention among Cambodian American men and women. Methods: The study group for this analysis included 87 individuals (39 men and 48 women) who were randomized to the experimental (HBV education) arm of our trial, participated in the CHW educational intervention, and provided follow-up data six months post-intervention. We examined HBV testing rates at follow-up, changes in HBV-related knowledge between baseline and follow-up, and barriers to HBV testing (that were reported to CHWs) by gender. Results: At follow-up, 15% of men and 31% of women reported they had received a HBV test (p=0.09). HBV-related knowledge levels increased significantly among both men and women. With respect to HBV testing barriers, women were more likely than men to cite knowledge deficits, and men were more likely than women to cite logistic issues. Discussion: Our study findings indicate that CHW interventions can positively impact knowledge among Cambodian American men, as well as women. They also suggest CHW interventions may be less effective in promoting the use of preventive procedures by Cambodian American men than women. Future CHW research initiatives should consider contextual factors that may differ by gender and, therefore, potentially influence the relative effectiveness of CHW interventions for men versus women.
Nonami, Atsushi,Sattler, Martin,Weisberg, Ellen,Liu, Qingsong,Zhang, Jianming,Patricelli, Matthew P.,Christie, Amanda L.,Saur, Amy M.,Kohl, Nancy E.,Kung, Andrew L.,Yoon, Hojong,Sim, Taebo,Gray, Natha American Society of Hematology 2015 Blood Vol.125 No.20
<P>Oncogenic forms of NRAS are frequently associated with hematologic malignancies and other cancers, making them important therapeutic targets. Inhibition of individual downstream effector molecules (eg, RAF kinase) have been complicated by the rapid development of resistance or activation of bypass pathways. For the purpose of identifying novel targets in NRAS-transformed cells, we performed a chemical screen using mutant NRAS transformed Ba/F3 cells to identify compounds with selective cytotoxicity. One of the compounds identified, GNF-7, potently and selectively inhibited NRAS-dependent cells in preclinical models of acute myelogenous leukemia and acute lymphoblastic leukemia. Mechanistic analysis revealed that its effects were mediated in part through combined inhibition of ACK1/AKT and of mitogen-activated protein kinase kinase kinase kinase 2 (germinal center kinase). Similar to genetic synthetic lethal approaches, these results suggest that small molecule screens can be used to identity novel therapeutic targets in cells addicted to RAS oncogenes.</P>
Lim, Byung-Kwan,Xiong, Dingding,Dorner, Andrea,Youn, Tae-Jin,Yung, Aaron,Liu, Taylor I.,Gu, Yusu,Dalton, Nancy D.,Wright, Adam T.,Evans, Sylvia M.,Chen, Ju,Peterson, Kirk L.,McCulloch, Andrew D.,Yajim American Society for Clinical Investigation 2008 The Journal of clinical investigation Vol.118 No.8
<P>The coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein that belongs to the family of adhesion molecules. In the postnatal heart, it is localized predominantly at the intercalated disc, where its function is not known. Here, we demonstrate that a first degree or complete block of atrioventricular (AV) conduction developed in the absence of CAR in the adult mouse heart and that prolongation of AV conduction occurred in the embryonic heart of the global CAR-KO mouse. In the cardiac-specific CAR-KO (CAR-cKO) mouse, we observed the loss of connexin 45 localization to the cell-cell junctions of the AV node but preservation of connexin 40 and 43 in contracting myocardial cells and connexin 30.2 in the AV node. There was also a marked decrease in beta-catenin and zonula occludens-1 (ZO-1) localization to the intercalated discs of CAR-cKO mouse hearts at 8 weeks before the mice developed cardiomyopathy at 21 weeks of age. We also found that CAR formed a complex with connexin 45 via its PSD-95/DigA/ZO-1-binding (PDZ-binding) motifs. We conclude that CAR expression is required for normal AV-node conduction and cardiac function. Furthermore, localization of connexin 45 at the AV-node cell-cell junction and of beta-catenin and ZO-1 at the ventricular intercalated disc are dependent on CAR.</P>
Anxiety Symptoms and Associated Psychological and Job-Related Factors Among Hospital Nurses
Eun Hyun Seo,Jae-Hon Lee,Arlene MacDougall,Nancy Liu,Alexander Hofkirchner,Simran Sharma,Mohamad Elfakhani,Hyung-Jun Yoon 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.1
Objective Recently, burnout and mental health issues regarding nurses are reported increasingly. This study aimed to investigate the prevalence of anxiety symptoms among hospital nurses and determine their association with psychological and job-related factors.Methods Data on demographics, job-related characteristics, burnout, Type A behavior patterns, self-esteem, and happiness were collected from 515 nurses working at a university hospital in Korea. Anxiety symptoms were assessed using the anxiety subscale of the Hospital Anxiety and Depression Scale, with scores of 8 or higher indicating the presence of anxiety symptoms. Demographic, job-related, and psychological factors were compared according to the presence of anxiety. Logistic regression was conducted to identify factors associated with anxiety symptoms.Results Two hundred and four (39.6%) participants had anxiety symptoms. Self-esteem and happiness were associated with a lower risk of anxiety symptoms, whereas burnout was associated with a higher risk of anxiety symptoms. Furthermore, being female, having a career of less than five years, and requiring counseling due to stress were associated with a higher risk of anxiety symptoms. Being younger, female, or a basic nurse; having a career of less than five years; partaking in shift work; experiencing job dissatisfaction; requiring counseling due to stress; being exposed to higher levels of burnout; and having lower levels of self-esteem and happiness were all found to be significantly correlated with anxiety symptoms.Conclusion These findings suggest that promoting self-esteem and happiness while reducing burnout may be beneficial in preventing and managing anxiety symptoms among hospital nurses.
Wang, Li,Chen, Ken Chung,Gao, Yaozong,Shi, Feng,Liao, Shu,Li, Gang,Shen, Steve G. F.,Yan, Jin,Lee, Philip K. M.,Chow, Ben,Liu, Nancy X.,Xia, James J.,Shen, Dinggang Published for the American Association of Physicis 2014 Medical physics Vol.41 No.4
<P>Cone-beam computed tomography (CBCT) is an increasingly utilized imaging modality for the diagnosis and treatment planning of the patients with craniomaxillofacial (CMF) deformities. Accurate segmentation of CBCT image is an essential step to generate three-dimensional (3D) models for the diagnosis and treatment planning of the patients with CMF deformities. However, due to the poor image quality, including very low signal-to-noise ratio and the widespread image artifacts such as noise, beam hardening, and inhomogeneity, it is challenging to segment the CBCT images. In this paper, the authors present a new automatic segmentation method to address these problems.</P>