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Zu Hao Huang,Nai Fa Liu,Li Xun Zhang,Yi An Xiao,Jin Long 한국유전학회 2008 Genes & Genomics Vol.30 No.3
The taxonomic status of the subspecies Alectoris chukar remains unclear since 1830. To obtain more information on phylogenetic relationships within the species, the entire mitochondrial DNA (mtDNA) control-region sequences of eleven subspecies were analyzed to construct the phylogenetic tree among the subspecies of chukar partridge. There was a significant genetic differentiation among the subspecies with little gene flow. The phylogenetic tree grouped all the eleven subspecies into a monophyletic cluster, which included two deeply divergent phylogroups. Haplotype network was observed within A. chukar, and gene flow estimates suggest isolation among the subspecies. Our data confirmed a locality of origin (central Asia) for chukar partridge, and have clarified the relationships among the subspecies. A conventional calibration of mtDNA sequence divergence indicated an early to middle Pleistocene evolution of the main clades in A. chukar, which could have diversified in allopatry in the lowland of continental Asia. Cyclic changes in Pleistocene climate and landscape might result in subspecific divergence of chukar partridge.
Tanshinone IIA Reverses the Malignant Phenotype of SGC7901 Gastric Cancer Cells
Xu, Min,Cao, Fa-Le,Li, Nai-Yi,Liu, Yong-Qiang,Li, Yan-Peng,Lv, Chun-Lei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Backgrounds: Tanshinone IIA (TIIA), a phenanthrenequinone derivative extracted from Salvia miltiorrhiza BUNGE, has been reported to be a natural anti-cancer agent in a variety of tumor cells. However, the effect of TIIA on gastric cancer cells remains unknown. In the present study, we investigated the influence of TIIA on the malignant phenotype of SGC7901 gastric cancer cells. Methods: Cells cultured in vitro were treated with TIIA (0, 1, 5, $10{\mu}g/ml$) and after incubation for different periods, cell proliferation was measured by MTT method and cell apoptosis and cell cycling were assessed by flow cytometry (FCM). The sensitivity of SGC7901 gastric cancer cells to anticancer chemotherapy was investigated with the MTT method, while cell migration and invasion were examined by wound-healing and transwell assays, respectively. Results: TIIA (1, 5, $10{\mu}g/ml$) exerted powerful inhibitory effects on cell proliferation (P < 0.05, and P < 0.01), and this effect was time- and dose-dependent. FCM results showed that TIIA induced apoptosis of SGC7901 cells, reduced the number of cells in S phase and increased those in G0/G1 phase. TIIA also significantly increased the sensitivity of SGC7901 gastric cancer cells to ADR and Fu. Moreover, wound-healing and transwell assays showed that TIIA markedly decreased migratory and invasive abilities of SGC7901 cells. Conclusions: TIIA can reverse the malignant phenotype of SGC7901 gastric cancer cells, indicating that it may be a promising therapeutic agent.