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Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis
Okada, Y.,Suzuki, A.,Ikari, K.,Terao, C.,Kochi, Y.,Ohmura, K.,Higasa, K.,Akiyama, M.,Ashikawa, K.,Kanai, M.,Hirata, J.,Suita, N.,Teo, Y.Y.,Xu, H.,Bae, S.C.,Takahashi, A.,Momozawa, Y.,Matsuda, K.,Momoh University of Chicago Press [etc.] 2016 American journal of human genetics Vol.99 No.2
<P>Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from classical HLA genes is challenging. Here, we conducted a large-scale MHC fine-mapping analysis of rheumatoid arthritis (RA) in a Japanese population (6,244 RA cases and 23,731 controls) population by using HLA imputation, followed by a multi-ethnic validation study including east Asian and European populations (n=7,097 and 23,149, respectively). Our study identified an independent risk of a synonymous mutation at HLA-DOA, a non-classical HLA gene, on anti-citrullinated protein autoantibody (ACPA)-positive RA risk (p=1.4 x 10(-) 9), which demonstrated a cis-expression quantitative trait loci (cis-eQTL) effect on HLA-DOA expression. Trans-ethnic comparison revealed different linkage disequilibrium (LD) patterns in HLA-DOA and HLA-DRB1, explaining the observed HLA-DOA variant risk heterogeneity among ethnicities, which was most evident in the Japanese population. Although previous HLA fine-mapping studies have identified amino acid polymorphisms of the classical HLA genes as driving genetic susceptibility to disease, our study additionally identifies the dosage contribution of a non-classical HLA gene to disease etiology. Our study contributes to the understanding of HLA immunology in human diseases and suggests the value of incorporating additional ancestry in MHC fine-mapping.</P>
N. Matsuda,Y. Kasugai,Y. Sakamoto,H. Nakashima,H. Matsumura,H. Iwase,N. Kinoshitay,H. Hirayama,H. Yashima,N. Mokhov,A. Levering,D. Boehnlein,K. Vazili,L. Gary,S. Wayne,K. Oishi,T. Nakamura,K. Ishibash 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
Neutron spectra in high-energy region between 1 and 100 MeV in the shield configuration of the anti-proton target station and a 120-GeV proton beam at Fermi National Accelerator Laboratory (Fermilab) were determined using the reaction rate data obtained with the multi-foil activation method. Two kinds of methods were employed for the determination of neutron spectra: one is the fitting method which is newly developed in this work, another is the unfolding method with SAND-II code. The calculations were performed using the PHITS. From the comparison between the calculated and experimental neutron spectra, it concluded that the PHITS can be used for shielding design of highenergy proton accelerators.
Shielding Experiments under JASMIN Collaboration at Fermilab (I) Overview of the Research Activities
Y. Kasugai,N. Matsuda,Y. Iwamoto,Y. Sakamoto,H. Nakashima,H. Matsumura,N. Kinoshitay,H. Iwase,T. Sanami,M. Hagiwara,H. Hirayama,H. Yashima,N. Sigyo,H. Arakawa,K. Ishibashi,N. Mokhov,A. Leveling,D. Boe 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
Shielding experiments were started on 2007 using high-energy proton accelerator at Fermi National Accelerator Laboratory (Fermilab) under the collaborative study program of JASMIN: Japanese and American Study of Muon Interaction and Neutron Detection. In this series of papers entitled "Shielding experiments under JASMIN collaboration at Fermilab", the part of the results regarding neutron detection has been reported. This paper, as a first paper of the series, overview of the research activities are described, and experimental results on high-energy neutron transportation are presented in a viewpoint of neutron attenuation in steel shield and applicability of Moyer's model. In addition, deductions of a neutron spectrum in wide energy range between 1 eV and 100 MeV by means of the hybrid method using the current-readout Bonner sphere together with foil-activation technique are presented.
Y. H. Matsuda,T. Nakamura,K. Kuga,S. Nakatsuji,S. Michimura,T. Inami,N. Kawamura,M. Mizumaki 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
The valence state of Yb ions in β-YbAlB4 and its polymorph α-YbAlB4 has been investigated byusing X-ray absorption and emission spectroscopy in SPring-8 at temperatures from 2 to 280 K. Theobserved Yb valence is 2.78 ± 0.01 in β-YbAlB4 at 2 K by using the X-ray emission spectroscopy. The valence is found to gradually increase with increasing temperature toward the trivalent state,and the characteristic temperature of the valence fluctuation is expected to be about 290 K. Wealso found a small increase in the Yb valence ( 0.002) by applying a magnetic field of 32 T at40 K to β-YbAlB4.
Development of 1700V Hybrid Module with Si-IGBT and SiC-SBD for High Efficiency
T. Takaku,H. Wang,N. Matsuda,S. Igarashi,T. Nishimura,S. Miyashita,O. Ikawa 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
This paper describes about newly developed 1700V/400A hybrid module which consists of Si-IGBT and SiC-SBD. The static and dynamic characteristics were evaluated and the turn-on loss is 38% lower and the reverse recovery loss is 83% lower than the conventional all-Si IGBT module because of the reverse recovery current of SiC-SBD is very small to be an unipolar device. The radiation noise on hybrid module becomes higher with increasing collector current, but the peak value of the noise from hybrid module is almost same as the all-Si module if the collector current is less than 300A. In AC690V PWM inverter, the total power dissipation of hybrid module is 8% lower at 1 kHz and 29% lower at 10 kHz compare to the all Si module. Therefore the 1700V hybrid module is useful as a power module for an AC690V high efficiency inverter system such as wind power generation system and high voltage solar power generation system. This paper reports about the static and dynamic characteristics and the radiation noise measurement results on the 400A/1700V hybrid module.
Event Generator Models in the Particle and Heavy Ion Transport Code System; PHITS
Koji Niita,Y. Iwamoto,T. Sato,N. Matsuda,Y. Sakamoto,H. Nakashima,H. Iwase,L. Sihver 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
We present the event generator models incorporated in the particle and heavy ion transport code system PHITS. For the high energy nuclear reactions, we discuss the QMD model and the INC model followed by the statistical decay model. For low energy neutron transport by using the nuclear data, we propose a new model, in which we combine the evaluated nuclear data and the reaction models so as to describe all ejectiles of collision keeping the energy and momentum conservation. By this new model, we can estimate new quantities which are related to the higher order correlations beyond one-body observable, for an example, the deposit energy distribution in a cell, which cannot be obtained by the transport calculation based on the Boltzmann equation with the evaluated nuclear data.
M. Hagiwara,T. Sanami,K. Masumoto,Y. Iwamoto,N. Matsuda,Y. Sakamoto,Y. Nakane,H. Nakashima,Y. Uwamino 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
Nuclear data on proton-induced neutron and γ-ray production in the energy range from 10 to 20 MeV is important to estimate the shield design and activation of low-energy cyclotron facilities for medical use such as production of radiopharmaceuticals in positron emission tomography (PET). We have measured double-differential thick target yields (TTYs) of neutrons and γ-rays from a ^(18)O-enriched water (H^(18)_2O) target induced by 18 MeV protons in order to estimate leakage radiations from a cyclotron and the neutron-induced activation in the production process of the ^(18)F-tagged fluorodeoxyglucose (FDG) which is a common radiopharmaceuticals for PET. Neutrons and γ-rays were measured with 5.08 cm diameter × 5.08 cm long NE213 scintillators for eight laboratory angles between 15- and 150-degrees. After applying a neutron-γ-ray event separation using the pulse-shape-discrimination (PSD) technique the neutron and γ-ray events were analyzed by a time-of-flight (TOF) technique and an unfolding technique, respectively. The measured TTYs were compared with TENDL-2009 data library and the physical model calculations with MCNPX and PHITS. The calculated TTYs roughly agree with the measured data.
Applicability of the PHITS Code to Heavy Ion Accelerator Facilities
Koji Niita,H. Iwase,Y. Iwamoto,T. Sato,N. Matsuda,Y. Sakamoto,H. Nakashima,L. Sihver 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
PHITS, a general-purpose Particle and Heavy Ion Transport code System, has been used for various research fields such as radiation science, accelerator and its shielding design, space research, medical application and material research. In this paper, we present an overview of the PHITS code, particularly the heavy ion reaction model included in the code and the capability of the transport of charged particles and heavy ions under magnetic field and discuss the applicability of the PHITS code to heavy ion accelerator facilities by showing some examples of the analysis.