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- 검색키워드
- 저자 : Mvondo Marie Alfrede (검색결과 2 건)
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Marie Alfrede Mvondo,Jessica Darelle Ekenfack,Ste´phane Minko Essono,Harding Saah Namekong,Charline Florence Awounfack,Matthias W. Laschke,Dieudonne´ Njamen 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.6
High prevalence of endometriosis was reported in Asian women as a result of their traditionally high intake of soy foods during infancy. Soy is widely used in infant feeding after weaning from breast milk or cow milk. This study thus aimed to determine to what extent soy intake before puberty may contribute to the development of endometriosis. For this purpose, immature (6-week old) female rats were fed with various soy formulas (0%, 10%, 20%, 30%, 40%, 50%, and 60%). Normal control animals were fed with a soy-free diet. At 13 weeks of age, animals (except the normal control) underwent a transplantation surgery to establish endometriosis. Estradiol valerate and oxytocin were used to induce pelvic pain. Endometrial implant levels of glutathione (GSH) and malondialdehyde (MDA) allowed estimating tissue oxidative status. Physiological ovarian function was assessed by histological analysis of ovaries. Results showed that soy-fed animals grew faster than animals receiving a soy-free diet (P < .001). In animals supplemented with more than 10% of soy, the intensity of pelvic pain increased (P < .001) as well as the volume of ectopic foci. In addition, tissue levels of MDA and GSH increased (P < .001). The ovarian function was altered and the number of luteinized unruptured follicles increased. In conclusion, although animals supplemented with soy at the prepubertal stage displayed a good growth performance, regular soy consumption may promote the development and progress of endometriosis in adulthood, especially when soy content in food is more than 10%.
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Mvondo Marie Alfrede,Messongue Mbollo Nina-Sonia,Njamen Dieudonné 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.2
Tamoxifen is the most common hormonal treatment for estrogen receptor positive (ER+) breast cancer. However, the long-term use of tamoxifen was associated with increased risks of endometrial cancer. The literature suggests that combining tamoxifen with substances endowed with antiproliferative properties could increase tamoxifen’s chemopreventive benefit. The ethanol extract of Persea americana Mill. (Lauraceae) seeds was found exhibiting antiproliferative properties in vitro. The present study therefore aimed at evaluating the ability of such an extract to prevent tamoxifen-induced endometrial hyperplasia without changing its activity on the mammary gland. This study was performed in ovariectomized rats receiving simultaneously tamoxifen (by the intraperitoneal route) and the ethanol extract of P. americana seeds (by gavage) at doses of 25, 50, 100 and 200 mg/kg. Co-administrations were performed for 37 consecutive days and animals were sacrificed thereafter. Uterine and serum levels of estradiol and cholesterol were assessed. The oxidative status of the uterus was also evaluated. Histology of the uterus and the mammary gland was performed. Results showed that the ethanol extract of P. americana seeds did not alter tamoxifen-induced uterine steroidogenesis but reduced its proliferative effect by decreasing uterine epithelial height (p < 0.001). This antiproliferative effect was associated with increased uterine levels of malondi-aldehyde and antioxidant enzymes. On the mammary gland, the non-proliferative effect of tamoxifen was not altered by P. americana extract. In conclusion, the ethanol extract of P. americana seeds could be a complementary treatment to prevent tamoxifen-induced endometrial hyperplasia during the treatment of ER+ breast cancer.
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