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RISS 인기검색어
- 검색키워드
- 저자 : Muhammad Yulianto Listiawan (검색결과 3 건)
- 무료
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Onychomycosis Caused by Aspergillus in a Patient with Leprosy: A Case Report
Andrea Hertanto,Muhammad Yulianto Listiawan,Evy Ervianti,Afif Nurul Hidayati,Trisiswati Indranarum,Sunarso Suyoso,Linda Astari,Sylvia Anggraeni,Yuri Widia,Azalia Aprinda Bahat,Fitra Tri Kurniasari 대한의진균학회 2024 대한의진균학회지 Vol.29 No.1
Aspergillus spp., one of the most common nondermatophyte molds (NDMs) that cause onychomycosis, are saprophytic fungi that can act as zoonotic agents and cause various health issues, including onychomycosis, in humans. Predisposing factors for onychomycosis include nail trauma, immunosuppression, and occupation. Nails in patients with leprosy are prone to change and develop onychomycosis due to unrecognized trauma to the nail area. Here, we report the case of a 25-year-old woman with 2-month history of white patches in fingernails and toenails, which were also brittle and damaged. She was a veterinarian who had frequent, direct interaction with animals, particularly dogs and cats. She denied trauma prior to the manifestation of symptoms and was undergoing leprosy treatment, including corticosteroids for leprosy reactions. Examination with potassium hydroxide revealed hyphae, and the nail culture revealed growth of fungal colonies with the characteristics of A. flavus. She received four cycles of itraconazole at 400 mg/day. Two of the three afflicted nails showed complete cure, whereas one nail showed mycologic cure. A. flavus is frequently found in animals, including dogs and cats and might have been a source of Aspergillus transmission, suggesting the patient's occupation and immunosuppression as risk factors for onychomycosis. Onychomycosis due to Aspergillus, particularly A. flavus, responds well to itraconazole pulse monotherapy.
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Kartika Misalina,Muhammad Yulianto Listiawan,Rahmadewi,Dwi Murtiastutik,Cita Rosita Sigit Prakoeswa,Afif Nurul Hidayati,Budi Utomo 대한의진균학회 2024 대한의진균학회지 Vol.29 No.2
Background: Erythema nodosum leprosum (ENL) is an acute immunologic complication of multibacillary leprosy (MB) that causes systemic inflammation in various organs. It is a major factor contributing to morbidity, mortality, and financial hardship. ENL is diagnosed clinically, and objective indicators for severe conditions remain unexplored. Simple blood biomarkers that differentiate between different ENL disease severity levels are required. Neutrophilto- lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been widely studied as severity biomarkers of numerous neoplastic and inflammatory disorders. Objective: We examined NLR and PLR values at various ENL severities and their role as severe disease indicators for ENL. Methods: This cross-sectional retrospective study examined 246 patients with multibacillary leprosy—with and without ENL reactions and aged 18 and above—and calculated their NLR and PLR values. Then, we compared patients with mild and severe disease states to those without ENL. The severity classification was based on the ENLIST ENL Severity Score (EESS). To determine the NLR and PLR cutoff points of mild and severe ENL, a receiver operating characteristic (ROC) curve was constructed. Results: The NLR value for severe ENL was significantly higher than that for mild ENL (p < 0.05), with a severe disease cutoff point of 5.71 (95.7% sensitivity, 68.7% specificity). No significant differences were found in PLR between patients with mild and severe ENL. Conclusion: While PLR is not an effective assay for evaluating ENL severity, NLR is a potential biomarker for severe ENL reactions in patients with multibacillary leprosy.
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Determinants of Bacterial Vaginosis: A Retrospective Study
Nurdini Wilda Salsabila,Afif Nurul Hidayati,Evy Ervianti,Muhammad Yulianto Listiawan,Sawitri,Budi Utomo 대한의진균학회 2024 대한의진균학회지 Vol.29 No.2
Background: Among women who can have children, bacterial vaginosis (BV) is the most common cause of abnormal vaginal discharge. Due to its high prevalence and morbidity, it is crucial to prevent BV by addressing its risk factors. Objective: This study aimed to determine the incidence and determinants of BV in the sexually transmitted infection (STI) division of the Dermatovenereology Department at Dr. Soetomo Hospital in Surabaya. Methods: This retrospective analytical observational study was conducted using a cross-sectional approach. Electronic data from 56 patients were included in the study, covering the period from 2019 to 2022. The patients were divided into two groups: BV patients and controls. BV patients were diagnosed with BV by fulfilling three out of four Amsel criteria, while controls with typical vaginal discharge. Results: The study included 34 BV patients and 22 control patients. Bivariate analysis showed a significant correlation between the incidence of BV and the number of sexual partners (p = 0.009) and the use of intrauterine devices (IUD) (p = 0.002). Multivariate analysis confirmed that both factors were determinants of BV incidence, with IUD use being the most dominant determinant (95% CI 1.86~135.02, p = 0.01). Conclusion: The study found that the use of IUDs and the number of sexual partners significantly determined BV incidence.
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