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      저자 : Muhammad Sohail Zafar (검색결과 2 건)
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      • KCI등재

        Oral Tissue Engineering Progress and Challenges

        Muhammad Sohail Zafar,Zohaib Khurshid,Khalid Almas 한국조직공학과 재생의학회 2015 조직공학과 재생의학 Vol.12 No.6

        Tissue engineering is a multidisciplinary science. The progress of tissue engineering for dental tissues is promising and various dental soft and hard tissues have been regenerated successfully in vitro using stem cells. Prior to their applications practically, there are a number of challenges and unanswered questions that need to be resolved for further progress. It is expected that in next two to three decades, the field of dentistry will be changed significantly by the availability of innovative tissue engineered products in dental office. The objective of this review paper is to highlight the progress of tissue engineering for various dental hard and soft tissues such as enamel, dentin, alveolar bone, periodontium, oral mucosa, and salivary glands. In addition, the challenges in the progress of tissue engineering and future expectations have been discussed.

      • KCI등재

        Regenerative Potential of Platelet Rich Fibrin (PRF) for Curing Intrabony Periodontal Defects: A Systematic Review of Clinical Studies

        Shariq Najeeb,Zohaib Khurshid,Muhammad Atif Saleem Agwan,Shazia Akhbar Ansari,Muhammad Sohail Zafar,Jukka Pekka Matinlinna 한국조직공학과 재생의학회 2017 조직공학과 재생의학 Vol.14 No.6

        Platelet-rich fibrin (PRF) has been used in regenerative medicine and dentistry. Recently, its use has been advocated for regenerative periodontics and wound healing. The randomized control trials have assessed the regenerative efficacy of the PRF for restoring intrabony periodontal defects.The objectives are to critically analyze and appraise the currently available literature, focusing on the use of PRF in regenerating periodontal bone defects. An electronic search was conducted (PubMed/MEDLINE, Google Scholar, ISI-WOS). Various combinations of following keywords were used: ‘platelet-rich fibrin’, ‘intrabony’, ‘periodontal’, ‘bone defect’ and ‘guided tissue regeneration’.Asecondary search was conducted by analyzing the reference lists of the articles obtained in initial search. The final search resulted in 13 randomized controlled trials being included. Inmajority of studies, PRF resulted in better clinical/radiographic outcomes than open flap debridement and augmented therapeutic effects of bone grafts. The combination of bovine bone substitutes and PRF resulted in better performance compared to alone. Similarly better outcomes were observed while using PRF in combination with nanohydroxyapatite, metformin and demineralized freeze-dried bone allograft. It can be concluded that PRF produces better outcomes than open flap debridement alone and augments the regenerative effects of bone substitutes.

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