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        Halal Tourism in Indonesia: An Indonesian Council of Ulama National Sharia Board Fatwa Perspective

        ADINUGRAHA, Hendri Hermawan,NASUTION, Ismail Fahmi Arrauf,FAISAL, Faisal,DAULAY, Maraimbang,HARAHAP, Ikhwanuddin,WILDAN, T.,TAKHIM, Muhamad,RIYADI, Agus,PURWANTO, Agus Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.3

        The phenomenon of sharia-based tourism development has now become a necessity for the people of Indonesia and even for the global community. Therefore, we need rules and regulations that govern it, both rules relating to normative sharia and regulations governing implementation in a positive legal manner. The purpose of this research is to describe halal tourism in Indonesia in terms of the Indonesian Council of Ulama National Sharia Board (DSN-MUI) fatwa and the government regulation. This research is a conceptual review that uses literature research methods sourced from authoritative journals, books and documents and is still relevant to the study of halal tourism. The results showed that the large number of public requests for halal tourism visits in Indonesia resulted in the need for normative and positive regulation that regulates. Finally, the MUI issued and stipulated fatwa Number: 108/DSN-MUI/IX/2016 regarding the implementation of tourism based on sharia principles and West Nusa Tenggara Regional Regulation Number. 2 of 2016 concerning Halal Tourism. Overall, the halal tourism indicator according to the DSN-MUI fatwa Number: 108/DSN-MUI/X/2016 and West Nusa Tenggara Regional Regulation Number. 2 of 2016 the content is almost the same and interrelated with one another. The only difference is in the use of the term "sharia tourism" in the DSN- MUI fatwa while the content in the regional regulation (PERDA) uses the term "halal tourism".

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        Overlapping and non-overlapping roles of the class-I histone deacetylase-1 corepressors LET-418, SIN-3, and SPR-1 in Caenorhabditis elegans embryonic development

        Yukihiro Kubota,Yuto Ohnishi,Tasuku Hamasaki,Gen Yasui,Natsumi Ota,Hiromu Kitagawa,Arashi Esaki,Muhamad Fahmi,Masahiro Ito 한국유전학회 2021 Genes & Genomics Vol.43 No.5

        Background Histone deacetylase (HDAC)-1, a Class-I HDAC family member, forms three types of complexes, the nucleosome remodeling deacetylase, Sin3, and CoREST complexes with the specifc corepressor components chromodomainhelicase-DNA-binding protein 3 (Mi2/CHD-3), Sin3, and REST corepressor 1 (RCOR1), respectively, in humans. Objective To elucidate the functional relationships among the three transcriptional corepressors during embryogenesis. Methods The activities of HDA-1, LET-418, SIN-3, and SPR-1, the homologs of HDAC-1, Mi2, Sin3, and RCOR1 in Caenorhabditis elegans during embryogenesis were investigated through measurement of relative mRNA expression levels and embryonic lethality given either gene knockdown or deletion. Additionally, the terminal phenotypes of each knockdown and mutant embryo were observed using a diferential-interference contrast microscope. Finally, the functional relationships among the three corepressors were examined through genetic interactions and transcriptome analyses. Results Here, we report that each of the corepressors LET-418, SIN-3, and SPR-1 are expressed and have essential roles in C. elegans embryonic development. Our terminal phenotype observations of single mutants further implied that LET-418, SIN-3, and SPR-1 play similar roles in promoting advancement to the middle and late embryonic stages. Combined analysis of genetic interactions and gene ontology of these corepressors indicate a prominent overlapping role among SIN-3, SPR-1, and LET-418 and between SIN-3 and SPR-1. Conclusion Our fndings suggest that the class-I HDAC-1 corepressors LET-418, SIN-3, and SPR-1 may cooperatively regulate the expression levels of some genes during C. elegans embryogenesis or may have some similar roles but functioning independently within a specifc cell.

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