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RISS 인기검색어
- 검색키워드
- 저자 : Moustafa El-Houssinie (검색결과 2 건)
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Sahar M.A. Hassanein,Shaymaa M. Deifalla,Moustafa El-Houssinie,Somaia A. Mokbel 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.1
Background and Purpose Te neuroregenerative drug Cerebrolysin has demonstrated efcacy in improving cognition in adults with stroke and Alzheimer’s disease. Te aim of this study was to determine the efcacy and safety of Cerebrolysin in the treatment of communication defects in infants with severe perinatal brain insult. Methods A randomized placebo-controlled clinical trial was conducted in which 158 infants (age 6–21 months) with communication defects due to severe perinatal brain insult were enrolled; 120 infants completed the study. The Cerebrolysin group (n=60) received twice-weekly Cerebrolysin injections of 0.1 mL/kg body weight for 5 weeks (total of ten injections). Te placebo group (n=60) received the same amount and number of normal saline injections. Results Te baseline Communication and Symbolic-Behavior-Scale-Developmental Profle scores were comparable between the two groups. Afer 3 months, the placebo group exhibited improvements in the social (p<0.01) and speech composite (p=0.02) scores, with 10% and 1.5% increases from baseline, respectively. Te scores of the Cerebrolysin group changed from concern to no concern, with increases of 65.44%, 45.54%, 358.06%, and 96.00% from baseline in the social (p<0.001), speech (p<0.001), symbolic (p<0.001), and total (p<0.001) scores. Conclusions Cerebrolysin dramatically improved infants’ communication especially symbolic behavior which positively afected social interaction. Tese fndings suggest that cerebrolysin may be an efective and feasible way equivalent to stem cell therapy.
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Sahar M.A. Hassanein,Mohamed Hassan Nasr Eldin,Hanaa A. Amer,Adel E. Abdelhamid,Moustafa El-Houssinie,Abir Ibrahim 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.1
Background and Purpose Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of neurological handicap in developing countries. Human umbilical cord blood (hUCB) CD34-positive (CD34+) stem cells exhibit the potential for neural repair. We tested the hypothesis that hUCB CD34+ stem cells and other cell types [leukocytes and nucleated red blood cells (NRBCs)] that are up-regulated during the acute stage of perinatal asphyxia (PA) could play a role in the early prediction of the occurrence, severity, and mortality of HIE. Methods This case-control pilot study investigated consecutive neonates exposed to PA. The hUCB CD34+ cell count in mononuclear layers was assayed using a flow cytometer. Twenty full-term neonates with PA and 25 healthy neonates were enrolled in the study. Results The absolute CD34+ cell count (p=0.02) and the relative CD34+ cell count (CD34+%) (p<0.001) in hUCB were higher in the HIE patients (n=20) than the healthy controls. The hUCB absolute CD34+ cell count (p=0.04), CD34+% (p<0.01), and Hobel risk scores (p=0.04) were higher in patients with moderate-to-severe HIE (n=9) than in those with mild HIE (n=11). The absolute CD34+ cell count was strongly correlated with CD34+% (p<0.001), Hobel risk score (p=0.04), total leukocyte count (TLC) (p<0.001), and NRBC count (p=0.01). CD34+% was correlated with TLC (p=0.02). Conclusions hUCB CD34+ cells can be used to predict the occurrence, severity, and mortality of neonatal HIE after PA.
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