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Elsayed M. Abdel Bary,Ammar N. Harmal,Mona E. Ibrahim,Moustafa A. Gouda 한국섬유공학회 2020 Fibers and polymers Vol.21 No.12
Novel chitosan nanoparticles (SCN) were synthesized via reaction of chitosan with different concentration of 2-chloro-N-(3-methylisoxazol-5-yl) acetamide (5 %, 10 % and 15 %) at 70-80 oC for 7 h to give the grafted polymer, whichcondensed with cyclohexanone Mannich base 45 oC for 7 h to afford the corresponding (SCN). These were stirred withDeflazacort drug to achieve the Deflazacort loading (SCN), which, compressed with calcium starch glycolate (CaSgly) togive the corresponding tablets. The pH 2. 1 and concentration of SCN-10 %/CaSgly (1:4) was found to be importantparameters in controlling the release profiles.