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Lim, T. J.,Upadhyay, A. K.,Moossa, A. R.,Kassir, A. A.,Olefsky, J. M. 啓明大學校 醫科大學 1991 계명의대학술지 Vol.10 No.1
Peptide의 일종인 IAPP (islet associated polypoptide)의 gloucose metabolism에 대한 영향을 관찰하기 위해 8마리의 성숙한 잡종개를 사용 동물실험을 하여 다음과 같은 결론을 얻었다. 의식이 있는 개에서 5-50pmol/kg/mim의 IAPP의 infusion으로 순환 IAPP치가 basal보다 12-50배 상승을 보였다. 실험중 IAPP치가 glucose 또는 insulin homeostasis에 대해서는 영향을 미치지 않았다. IAPP의 정맥주사로 혈장 칼슘농도는 신속한 감소를 보였다. In this study we have administered constant intravenous infusions of IAPP, to conscious dogs during the euglycemic glucose clamp setting. The doses of IAPP used (5 and 50 pmol/kg/min) raised the circulating IAPP levels approxomately 12-fold and 50-fold above basal, respectively. Studies were conducted at two differnet insulin infusion rates, resulting in steady state plasma insulin levels of ∼610 and 2600 pmol. our results showed that the IAPP infusions did not lead to any measurable change in the insulin stimulated glucose disposal rate, at either insulin infusion rate. Additionally, no effect of IAPP on hepatic glucose production was observed. Intravenous glucose tolerance tests were also performed with and without a concomitant IAPP infusion and we found that IAPP had no influence on the glucose profile. Aithough we could not observe any effect of IAPP on any of the measured aspects of glucose or insulin metabolism, we did find a consistent hypocalcemic effect of this perptide. Shortly after the onset if IAPP on any of the measured aspects of glucose or insulin metabolism, we did find a consistent hypocalcemic effect of this peptide. Shortly after the onset of IAPP infusion. serum calcium levels fell by 10-15% and remained at these levels throughout the coures of the IAPP infusion. In summary: (1) infusion of IAPP at doses of 5 or 50 pmol/kg/min in conscious dogs raises the circulating IAPP level 12-to 50-fold above basal (2) During these infusion studies, no effect of IAPP was observed on any of the measured aspectes of glucose or insulin homeostasis. (3) IAPP leads to a prompt reduction in plasma calcium concentrations upon intravenous administration.