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Dynamic 18F-FDG PET for Assessment of Tumor Physiology in Two Breast Carcinoma Xenografts
Alexandr Kristian,Line B. Nilsen,Kathrine Roe,Mona-Elisabeth Revheim,Olav Engebråten,Gunhild M. Mælandsmo,Ruth Holm,Eirik Malinen,Therese Seierstad 대한핵의학회 2013 핵의학 분자영상 Vol.47 No.3
Purpose To compare dynamic 2-deoxy-2-[18F]fluoro-Dglucose positron emission tomography (18F-FDG PET) parameters in two selected human breast cancer xenografts and to evaluate associations with immunohistochemistry and histology. Procedures Dynamic 18F-FDG PETof luminal-like MAS98.06and basal-like MAS98.12 xenografts was performed, and the compartmental transfer rates (k1,k2,k3), blood volume fraction (vB) and metabolic rate of 18F-FDG(MRFDG) were estimated from pharmacokinetic model analysis. After sacrifice, analyses of hypoxia (pimonidazole), proliferation (Ki-67), vascularization (CD31), glucose transport receptor (GLUT1) and necrosis (HE)was performed. The level of hexokinase 2 (HK2) was estimated from Western blot analysis. Results The 18F-FDG uptake curves for the two xenografts were significantly different (p<0.05). k1 and vB were higher for MAS98.12 (p<0.01), while k3 was higher for MAS98.06(p<0.01). MAS98.12 had a higher fraction of stromal tissue and higher microvessel density (MVD), and it was less necrotic and hypoxic thanMAS98.06.MAS98.12 had stronger positive GLUT1 staining and lower Ki-67 than MAS98.06. In both models significant correlations were found between k1and the GLUT1 score, between k3 and the level of HK2, and between vB and MVD. Conclusions Significant differences in dynamic 18F-FDG parameters between the two human breast cancer xenografts were found. The differences could be explained by underlying histological and physiological characteristics.
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