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RISS 인기검색어
- 검색키워드
- 저자 : Mohammad Sadegh Nourbakhsh (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Encapsulation of Frankincense Essential Oil by Microfluidic and Bulk Approaches: A Comparative Study
Pouria Taherian,Mohammad Sadegh Nourbakhsh,Ali Abouei Mehrizi,Mohadeseh Hashemi 한국섬유공학회 2022 Fibers and polymers Vol.23 No.10
Herbs and hand-made herbal remedies have been long used for disease control, treatment, and healthimprovement. Evidence suggests that a single herb's compounds can have synergistic functions with probably no adverseeffect. Unfortunately, the traditional administration of essential oil (EO) does not follow a regulatory dose regimen, causingreduced bioavailability due to EO evaporation or denaturation in harsh biological environments. Hence, encapsulation canhelp enhance EO stability and dose dependence. Here, chitosan nanoparticles (ChNPs) were used to encapsulate frankincenseessential oil (FEO) to preserve its remarkable therapeutic effects. Also, traditional bulk preparation methods were comparedwith microfluidic with central aqueous stream configuration (CAS). The results indicated the higher quality of microfluidicbasednanoparticles with uniform, spherical, and separated morphologies. The size of bulk and microfluidic nanoparticlesranged from 86 to 118 nm, the surface charge varied from 12.5 to 19.5 for different amounts of FEO, and the as-preparedcolloid remained stable for three days. Narrow size distribution (PDI0.28) and high encapsulation efficiency (EE99 %)were achieved using the microfluidic process compared to the bulk method (PDI=0.74, EE90 %). The microfluidicnanoparticle also indicated a burst release rate greater than the bulk method (30 %). It was concluded that the highperformancemicrofluidic approach provided higher quality and more control over nanoparticle properties.
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Mahsa Janmohammadi,Mohammad Sadegh Nourbakhsh,Shahin Bonakdar 한국섬유공학회 2021 Fibers and polymers Vol.22 No.1
Skin tissue engineering is an evolving method to reconstruct skin damages caused by disease, burn or trauma. Inskin tissue engineering, scaffolds should prepare three-dimensional structure for skin cells. Electrospinning technique hasbeen widely applied for producing nano/micro-scale fiber scaffolds in tissue engineering. In this study, electrospun scaffoldsbased on polycaprolactone (PCL) and hyaluronic acid (HA) containing L-ascorbic acid (AA) were fabricated. Morphology,contact angle, functional groups, biodegradability and drug release of the scaffolds were evaluated. L929 fibroblast cellsseeded on nanofibrous scaffolds and cell attachment and viability were evaluated as well. According to the results, the fibersdiameter were less than 180 nm and by adding hyaluronic acid, the hydrophilicity of scaffolds increased and degradation ratewas adjusted. The encapsulation efficiency and successful release of ascorbic acid in nanofibrous scaffolds weredemonstrated. According to the results, the cell growth, proliferation and adhesion of L929 fibroblast cells on the PCL/HA/AA scaffolds were enhanced in comparison with the PCL scaffold. Moreover, PCL/HA (80:20) containing 40 mg of AAnanofibrous scaffold could be potentially applied for skin tissue engineering.
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Marjan Shabannejad,Mohammad Sadegh Nourbakhsh,Amir Salati,Zohreh Bahrami 한국섬유공학회 2020 Fibers and polymers Vol.21 No.8
In the present work, the biodegradable nanofibrous scaffolds containing poly(caprolactone) (PCL), poly(vinylalcohol) (PVA) and aloe vera (AV), through two nozzles electrospinning method, were prepared and characterized byscanning electron microscopy, Fourier transform infrared spectroscopy, contact angle measurement and mechanical analysis. The biocompatibility and cell growth were evaluated using MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazoliumbromide) assay. Adding poly(vinyl alcohol) (PVA) and poly(caprolactone) (PCL) boosted the electrospinability of aloe vera(AV) solution and mechanical features of the scaffolds. According to the Scanning electron microscopy (SEM) results,uniform PVA/AV-PCL nanofibers were fabricated with the average diameter about 119±11.78 nm. Fourier-transform infraredspectroscopy) FTIR (confirmed the presence of functional groups of scaffolds. The results of the contact angle showed thatby adding aloe vera, the hydrophilicity increased. The results showed that the tensile strength of samples with 6 mg/ml AV,reached to 2.02 MPa. MTT results showed that all samples had a cell viability of over 80 %. It can be concluded thatnanofibrous scaffolds with concentration of 6 mg/ml, distance between syringe tip/collector of 15 cm, feed rate of 3 ml/h andapplied voltage of 12 kV, have appropriate properties for skin tissue engineering by stimulating the fibroblast cells andtherefore accelerating the regeneration processes of damaged skin.
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