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Effect of Impeller Blade Number on Kla in Mechanically Agitated Vessels
Lu Wei Ming,Wu Hong Zhang,Chou Cheng Ying 한국화학공학회 1999 Korean Journal of Chemical Engineering Vol.16 No.5
Effects of impeller blade number on gas dispersion and mass transfer rate were thoroughly investigated for mechanically agitated vessels equipped with 2-, 4-, 6- and 8-straight blades disk turbine impellers. The results show that under the same rotational speed, the impeller with more blades always can disperse gas more effectively, which induces a higher value of $lt;K_La$gt;. However, with the same total power consumption, the 4-blade impeller can obtain a higher $lt;K_La$gt; value than the 6- and 8-blade impellers under a lower gassing rate condition (Q-g$lt;0.5vvm), but if Q_g) exceeds 0.5vvm, the 6-blade impeller will perform better than the 4- and 8- blade impellers. To examine the results obtained from the single impeller systems, the same approach is applied to measure $lt;K_La$gt; values for the triple stage 6-blade impeller system (3×6) and quadruple stage 4-blade impeller system (4×4). From the experimental results, it can be found that the 4×4 system gives higher $lt;K_La$gt; value than the 3×6 system under gas completely dispersed conditions. By correlating $lt;K_La$gt; with n_b, N and V_s, the following correlation can be given as: $lt;K_La$gt; = 0.00119n^(0.62)_bN^(1.56)V^(0.4)_s $lt;K_La$gt; = 0.0297n^(0.1)_b(P_s/V)^(0.34)V^(0.48)_s These two correlations can also be used to evaluate the mass transfer coefficient of each impeller region for the multiple impeller systems and the deviation is always less than 10%.
Wei, Wei-Hong,Cai, Xiu-Yu,Xu, Tao,Zhang, Guo-Yi,Wu, Yong-Feng,Feng, Wei-Neng,Lin, Li,Deng, Yan-Ming,Lu, Qiu-Xia,Huang, Zhe-Li Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3
Background and Purpose: Cisplatin is the most common chemotherapeutic agent for loco-regionally advanced nasopharyngeal carcinoma (NPC); however, toxicity is a limiting factor for some patients. We retrospectively compared the efficacy and toxicity of weekly docetaxel-based and cisplatin-based concurrent chemoradiotherapy in loco-regionally advanced NPC. Methods and Materials: Eighty-four patients with Stage III and IVA-B NPCs, treated between 2007 and 2008, were retrospectively analyzed. Thirty received weekly docetaxel-based concurrent chemotherapy, and 43 were given weekly cisplatin-based concurrent chemotherapy. Radiotherapy was administered using a conventional technique (seven weeks, 2.0 Gy per fraction, total dose 70-74 Gy) with 6-8 Gy boosts for some patients with locally advanced disease. Results: Median follow-up time was 42.3 months (range, 8.6-50.8 months). There were no significant differences in the 3-year loco-regional failure-free survival (85.6% vs. 92.3%; p=0.264), distant failure-free survival (87.0% vs. 92.5%; p=0.171), progression-free survival (85.7% vs. 88.4%; p=0.411) or overall survival (86.5% vs. 92.5%, p=0.298) of patients treated concurrently with docetaxel or cisplatin. Severe toxicity was not common in either group. Conclusions: Weekly docetaxel-based concurrent chemoradiotherapy is potentially effective and has a tolerable toxicity; however, further investigations are required to determine if docetaxel is superior to cisplatin for advanced stage NPC.
GOLPH3, a Good Prognostic Indicator in Early-stage NSCLC Related to Tumor Angiogenesis
Lu, Ming,Tian, Yu,Yue, Wei-Ming,Li, Lin,Li, Shu-Hai,Qi, Lei,Hu, Wen-Si,Gao, Cun,Si, Li-Bo,Tian, Hui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Background: Golgi phosphoprotein-3 (GOLPH3) is implicated in cancer development and progression. The aim of this study was to evaluate the prognostic significance of GOLPH3 protein and its association with tumor angiogenesis in patients with early-stage NSCLC. Materials and Methods: Immunohistochemistry was performed to determine GOLPH3 protein expression and allow assessment of intratumoral microvessel density (MVD) by counting CD-34 positive immunostained endothelial cells. Correlations of expression with MVD, clinicopathologic features and clinical prognosis were analyzed. Results: A notably higher level of GOLPH3 expression was found in early-stage NSCC tissues at the protein level. However, we do not find any correlation between GOLPH3 expression and clinicopathologic features (p>0.05), although higher MVD was positively associated with GOLPH3 overexpression (p<0.001). Expression of GOLPH3 was found to be an independent prognostic factor in early-stage NSCLC patients, those expressing high levels of GOLPH3 exhibiting a substantially lower 5-year overall survival than GOLPH3-negative patients (adjusted HR =1.899, 95% CI: 1.021-3.532, p=0.043). Conclusions: High expression of the GOLPH3 protein is common in early-stage NSCC, and is closely associated with tumor progression, increased tumor angiogenesis, and poor survival. We conclude a possibility of its use as a diagnostic and prognostic marker in early-stage NSCC patients.
Innate Immune Response of NNV Infection in Fish and Its Disease Prevention
Lu, Ming-Wei,Wu, Jen-Leih The Korean Society for Marine Biotechnology 2007 한국해양바이오학회지 Vol.2 No.3
The innate immune response which is seen as the initial defense mechanism induced upon foreign invasion has been well documented in higher vertebrates. This has also been observed in fish infected with NNV. However, the fish immune system based on fully established genome project has not been fully elucidated. Therefore, in this review, we hope to correlate NNV infection in fish that has devastated the aquaculture industry, to its host immune system. Further, we discuss the potential preventive measures in overcoming the widespread of this neurodisease.
RESEARCH PAPERS : Effect of Impeller Blade Number on KLa in Mechanically Agitated Vessels
(Wei Ming Lu),(Hong Zhang Wu),(Cheng Ying Chou) 한국화학공학회 1999 Korean Journal of Chemical Engineering Vol.16 No.5
Effects of impeller blade number on gas dispersion and mass transfer rate were thoroughly investigated for mechanically agitated vessels equipped with 2-, 4-, 6- and 8-straight blades disk turbine impellers. The results show that under the same rotational speed, the impeller with more blades always can disperse gas more effectively, which induces a higher value of $lt;K_La$gt;. However, with the same total power consumption, the 4-blade impeller can obtain a higher $lt;K_La$gt; value than the 6- and 8-blade impellers under a lower gassing rate condition (Q-g$lt;0.5vvm), but if Q_g) exceeds 0.5vvm, the 6-blade impeller will perform better than the 4- and 8- blade impellers. To examine the results obtained from the single impeller systems, the same approach is applied to measure $lt;K_La$gt; values for the triple stage 6-blade impeller system (3×6) and quadruple stage 4-blade impeller system (4×4). From the experimental results, it can be found that the 4×4 system gives higher $lt;K_La$gt; value than the 3×6 system under gas completely dispersed conditions. By correlating $lt;K_La$gt; with n_b, N and V_s, the following correlation can be given as: $lt;K_La$gt; = 0.00119n^(0.62)_bN^(1.56)V^(0.4)_s $lt;K_La$gt; = 0.0297n^(0.1)_b(P_s/V)^(0.34)V^(0.48)_s These two correlations can also be used to evaluate the mass transfer coefficient of each impeller region for the multiple impeller systems and the deviation is always less than 10%.
Stability Analysis of Perforated Plate Type Single Stage Suspension Fluidized Bed Without Downcomer
Lu, Wei Ming,Ju, Sheau Pyng,Tung, Kuo Lun,Lu, Yu Chang 한국화학공학회 1999 Korean Journal of Chemical Engineering Vol.16 No.6
The stability of operation of a perforated plate type suspension bed without downcomer was analyzed experimentally and numerically. The effects of the feed rate, the gas flowrate and the opening ratio and hole diameter of the perforated plates on the operating stability of the fluidized bed were examined. A full three-dimensional discrete particle simulation method proposed by Tsuji [1993] was performed to study the formation of a stable suspension fluidized bed. The course and behavior of particles that formed a dense and stable fluidized bed are discussed. Both the experimental and simulation results of this study show that the process of forming a suspension bed can be categorized into (i) an induced stage, (ii) a growing stage, and (iii) a stable stage. The velocity of gas through the orifice directly controls the formation of the bed while the solid flow rate over a considerable range maintains a balanced hold-up in the suspension bed system without downcomers. The existence of a multiplicity of steady states corresponding to different gas flow rates, for the same feed rate and perforated plate type, was observed. Results show that the design of the plate, the particle feed rate and the gas velocity distribution through the hole affect the stability of the fluidized bed. The simulated results agree qualitatively well with experimental observations.
The modal characteristics of non-uniform multi-span continuous beam bridges
Lu-ning Shi,Wei-ming Yan,Hao-xiang He 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.52 No.5
According to the structure characteristics of the non-uniform beam bridge, a practical model for calculating the vibration equation of the non-uniform beam bridge is given and the application scope of the model includes not only the beam bridge structure but also the non-uniform beam with added masses andelastic supports. Based on the Bernoulli-Euler beam theory, extending the application of the modal perturbation method and establishment of a semi-analytical method for solving the vibration equation of thenon-uniform beam with added masses and elastic supports based is able to be made. In the modal subspace of the uniform beam with the elastic supports, the variable coefficient differential equation that describes the dynamic behavior of the non-uniform beam is converted to nonlinear algebraic equations. Extending the application of the modal perturbation method is suitable for solving the vibration equation of the simply supported and continuous non-uniform beam with its arbitrary added masses and elastic supports. The examples, that are analyzed, demonstrate the high precision and fast convergence speed of the method. Further study of the timesaving method for the dynamic characteristics of symmetrical beam and the symmetry of mode shape should be developed. Eventually, the effects of elastic supports and added masseson dynamic characteristics of the three-span non-uniform beam bridge are reported.