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- 저자 : Mijakovic, Ivan (검색결과 1 건)
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Triterpenoid-biosynthetic UDP-glycosyltransferases from plants
Rahimi, Shadi,Kim, Jaewook,Mijakovic, Ivan,Jung, Ki-Hong,Choi, Giltsu,Kim, Sun-Chang,Kim, Yu-Jin Elsevier 2019 BIOTECHNOLOGY ADVANCES Vol.37 No.7
<P><B>Abstract</B></P> <P>Triterpenoid saponins are naturally occurring structurally diverse glycosides of triterpenes that are widely distributed among plant species. Great interest has been expressed by pharmaceutical and agriculture industries for the glycosylation of triterpenes. Such modifications alter their taste and bio-absorbability, affect their intra−/extracellular transport and storage in plants, and induce novel biological activities in the human body. Uridine diphosphate (UDP)-glycosyltransferases (UGTs) catalyze glycosylation using UDP sugar donors. These enzymes belong to a multigene family and recognize diverse natural products, including triterpenes, as the acceptor molecules. For this review, we collected and analyzed all of the UGT sequences found in <I>Arabidopsis thaliana</I> as well as 31 other species of triterpene-producing plants. To identify potential UGTs with novel functions in triterpene glycosylation, we screened and classified those candidates based on similarity with UGTs from <I>Panax ginseng</I>, <I>Glycine</I> max, <I>Medicago truncatula</I>, <I>Saponaria vaccaria</I>, and <I>Barbarea vulgaris</I> that are known to function in glycosylate triterpenes. We highlight recent findings on UGT inducibility by methyl jasmonate, tissue-specific expression, and subcellular localization, while also describing their catalytic activity in terms of regioselectivity for potential key UGTs dedicated to triterpene glycosylation in plants. Discovering these new UGTs expands our capacity to manipulate the biological and physicochemical properties of such valuable molecules.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Potential triterpene-related UGT candidates are classified based on the similarity with the UGTs with known function in triterpene glycosylation. </LI> <LI> Substrate specificities are suggested among triterpene biosynthesis UGT candidates. </LI> <LI> UGTs grouping based on PSPG motif involved in sugar donor specificity is presented. </LI> <LI> MeJA inducibility, physiological function, tissue expression, catalytic characteristics of triterpene biosynthesis UGTs are discussed. </LI> <LI> Regioselectivity and catalytic characteristic of triterpene biosynthesis UGTs are described. </LI> </UL> </P>
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