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      저자 : Michiko Kumagai (검색결과 1 건)
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        Effectiveness of monthly intravenous ibandronate injections in a realworld setting: Subgroup analysis of a postmarketing observational study

        Yasuhiro Takeuchi,Junko Hashimoto,Hiroyuki Kakihata,Yousuke Nishida,Michiko Kumagai,Chiemi Yamagiwa 대한골다공증학회 2019 Osteoporosis and Sarcopenia Vol.5 No.1

        Objectives: The favorable safety and consistent effectiveness of monthly intravenous (IV) ibandronate injections was demonstrated in a prospective, postmarketing, observational study in Japanese patients with osteoporosis. Here, we present subgroup analyses from the study. Methods: Lumbar spine (L2e4) bone mineral density (BMD) gains were assessed in the following subgroups: aged <75 or 75 years, absence or presence of vertebral fractures, previous bisphosphonate (BP) treatment, and concomitant versus naïve osteoporosis drug treatment. The cumulative incidence of fractures and relative change in bone turnover markers were also examined. Results: Of 1062 enrolled patients, 1025 received monthly IV ibandronate 1mg and were assessed for 12 months. BMD gains with ibandronate were comparable, irrespective of older age or prevalent fractures. Overall, 515 patients (50.2%) had previously received osteoporosis treatment; of these, 166 (16.1%) received other BPs. Mean BMD changes were 3.69% (95% confidence interval [CI], 0.89%e6.50%) in patients previously treated with other BPs, and 4.26% (95% CI, 2.88%e5.64%) in patients who had not received prior osteoporosis treatment. Among the 510 patients (49.7%) concomitantly prescribed active vitamin D drugs, mean BMD changes were 5.74% (95% CI, 2.53%e8.95%) with eldecalcitol versus 3.54% (95% CI, 1.98%e5.10%) with ibandronate alone. The lowest fracture incidence was observed with the combination of ibandronate and eldecalcitol, but differences between the subgroups were not statistically significant. Conclusions: Monthly IV ibandronate demonstrated comparable BMD gains in the patient subgroups analyzed. Concomitant use of ibandronate with eldecalcitol showed a trend of higher BMD gains and lower fracture incidence than ibandronate alone.

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