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RISS 인기검색어
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- 저자 : Mertsoylu, Huseyin (검색결과 4 건)
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Mertsoylu, Huseyin,Muallaoglu, Sadik,Besen, Ayberk Ali,Erdogdu, Suleyman,Sezer, Ahmet,Sedef, Ali Murat,Kose, Fatih,Arican, Ali,Ozyilkan, Ozgur Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Background: The aim of this study was to assess the epidemiological and clinicopathological characteristics of primary extranodal non-Hodgkin's lymphoma (pENL) patients, focusing on treatment and survival outcome. Materials and Methods: Between October 2003 and March 2012, 802 patients with non-Hodgkin's lymphoma (NHL) were diagnosed and treated in two different cancer centers of Southern Turkey. Results: pENL, constituted 12.4% (100/802) of all NHL studied during this period. Median age of the patients was 56 years (range 17-87 years) and the male: female distribution was 3:2. Eighty-five of 100 patients (85%) were in stage I/II, 9/100 (9%) in stage III, whereas 6/100 (6%) were in stage IV. Head and neck constituted the most common site (51/100, 51%), followed by gastrointestinal tract (GIL) (37/100, 37%), and cerebrum (CL) (5/100, 5%). Diffuse large B cell lymphoma (DLBCL) was the most common histological type, observed in 53% of patients, followed by marginal zone extranodal lymphoma (13%). Most of patients (76%) received a CHOP containing regimen. Complete remission (CR) were achieved in 71% of patients. The median follow-up duration of all patients was reported as 37.6 months (range, 0.8-165 months). This period was reported as 137.5 months (range, 117.5-1578.6 months) in gastrointestinal lymphoma (GIL) patients, 119.0 months (range, 91.8-146.1 months) in head and neck lymphoma (HNL) patients, and 18.4 months (range, 12.6-24.1 months) in cerebral lymphoma (CL) patients. Conclusions: Head and neck, and the gastrointestinal tract were the two most common extranodal sites observed. Histologically DLBC accounted for the majority of cases. Most patients were on earlier stages, had low-low intermediate IPI scores and had a favorable prognosis.
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( Munevver Mertsoylu Aydin ),( Meral Mert ),( Yildiz Okuturlar ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Although Inhaled corticosteroids (ICS) have been considered as a safe therapy, some systemic effects may be observed. Many patients with type 2-diabetes have an indication to use inhaled corticosteroids (ICS) for coexisting asthma or COPD. But their effect on glucose metabolism in patients with type 2 diabetes has not been well defined. The aim of the study was to investigate the effect of ICS`s on glucose level on the inpatient with COPD acute exacerbation. Methods: 25 (female/male: 16/9) patients were enrolled the study. The glucose levels were recorded for a week while their oral antidiabetic therapy continues. Alc, CRP levels were measured on admission. Statistical analyses were performed on glucose change due to steroids. Results: Mean ages were found 68.8 9.91 years in female and 67 12.18 years in male patients respectively. No significant difference was found between two groups (p>0,05). There were no significant differences on the first, second, third, fourth, fifth and sixth days of week in all patients. We found significant difference in glucose level on between the first (151.32±58.902) and seventh days (205.28±99.192) (p= 0.043) and also eighth day (221.88±111.061) (p=0.017). Parenteral steroids added on 11 patients during clinical course. We compared the patients with and without parenteral steroids about glucose levels. There is a significant difference in glucose levels on seventh day between those two groups. Conclusions: Steroids are known as agents which affect glucose level. Inhaler steroid usage even causes increasing glucose levels in prolonged periods and it is more apparent during intravenous steroid treatment.
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Lack of Prognostic Significance of C-erbB-2 Expression in Low- and High- grade Astrocytomas
Muallaoglu, Sadik,Besen, Ali Ayberk,Ata, Alper,Mertsoylu, Huseyin,Arican, Ali,Kayaselcuk, Fazilet,Ozyilkan, Ozgur Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
Background: Astrocytic tumors, the most common primary glial tumors of the central nervous system, are classified from low to high grade according to the degree of anaplasia and presence of necrosis. Despite advances in therapeutic management of high grade astrocytic tumors, prognosis remains poor. In the present study, the frequency and prognostic significance of c-erb-B2 in astrocytic tumors was investigated. Materials and Methods: Records of 72 patients with low- and high-grade astrocytic tumors were evaluated. The expression of C-erbB-2 was determined immunohistochemically and intensity was recorded as 0 to 3+. Tumors with weak staining (1+) or no staining (0) were considered Her-2 negative, while tumors with moderate (2+) and strong (3+) staining were considered Her-2 positive. Results: Of the 72 patients, 41 (56.9%) had glioblastoma (GBM), 10 (13.9%) had diffuse astrocytoma, 15 (20.8%) had anaplastic astrocytoma, 6 (8.3%) had pilocytic astrocytoma. C-erbB-2 overexpression was detected in the tumor specimens of 17 patients (23.6%). Six (8.3%) tumors, all GBMs, exhibited strong staining, 2 (2.7%) specimens, both GBMs, exhibited moderate staining, and 9 specimens, 5 of them GBMs (12.5%), exhibited weak staining. No staining was observed in diffuse astrocytoma and pilocytic astrocytoma specimens. Median overall survival of patients with C-erbB-2 negative and C-erbB-2 positive tumors were 30 months (95%CI: 22.5-37.4 months) and 16.9 months (95%CI: 4.3-29.5 months), respectively (p=0.244). Conclusions: Although there was no difference in survival, C-erbB-2 overexpression was observed only in the GBM subtype.
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Erkan Topkan,Ugur Selek,Hüseyin Mertsoylu,Yurday Ozdemir,Ahmet Kucuk,Nese Torun,Ali Ayberk Besen 대한이비인후과학회 2020 Clinical and Experimental Otorhinolaryngology Vol.13 No.4
Objectives. To investigate the influence of pretreatment primary tumor or nodal photopenia (PP) on 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT), an indicator of tumor ischemia, on survival results of nasopharyngeal cancers (NPCs) treated with concurrent chemoradiotherapy (C-CRT). Methods. The pre-C-CRT FDG PET-CT scans of 104 patients with NPC (cT1-4 N0-3 M0) were retrospectively examined to determine the presence of PP (PP+). Our primary endpoint was the influence of PP+ on overall survival (OS), while the progression-free survival (PFS) and locoregional PFS (LRPFS) constituted the secondary endpoints. Results. The PP+ was detected in 29 (27.9%): nine (8.7%), seven (6.7%), and 13 (12.5%) in the primary tumor alone, primary tumor plus neck nodes, and neck nodes alone, respectively. Because the PP+ cases were small by count per location, all comparative analyses were performed according to overall PP+/ PP– status instead of per detected site. At a median follow-up of 67.8 months (range, 9 to 130 months), the median survival times were not reached (NR) for the entire population, while 5-year OS, LRPFS, and PFS rates were 73.3%, 68.2%, and 63.4%, respectively. Comparatively the PP+ patients exhibited significantly poorer median OS (49.8 months vs. NR, P<0.001), LRPFS (40.7 months vs. NR, P=0.001), and PFS (31.8 months vs. NR, P=0.002) durations than their PP– counterparts. Furthermore, the PP+ retained its independent prognostic significance in multivariate analysis (P<0.001). Conclusion. Present results uncovered the pre-C-CRT PP as an independent predictor of poor prognosis for NPC patients, which underscore the requirement for the fortification of the local and systemic treatments in hypoxic NPCs.
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