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Youcui Xu,Yi Wu,Yi Hu,Mengran Xu,Yanyan Liu,Yuting Ding,Jing Chen,Xiaowan Huang,Longping Wen,Jiabin Li,Chen Zhu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background The high mortality associated with drug-resistant bacterial infections is an intractable clinical problem resulting from the low susceptibility of these bacteria to antibiotics and the high incidence of recurrent infections. Methods Herein, a photosynthetic bacteria-based multiplex system (Rp@Al) composed of natural Rhodopseudomonas palustris (Rp) and Food and Drug Administration-approved aluminum (Al) adjuvant, was developed to combat drug-resistant bacterial infections and prevent their recurrence. We examined its photothermal performance and in vitro and in vivo antibacterial ability; revealed its protective immunomodulatory effect; verified its preventative effect on recurrent infections; and demonstrated the system’s safety. Results Rp@Al exhibits excellent photothermal properties with an effective elimination of methicillin-resistant Staphylococcus aureus (MRSA). In addition, Rp@Al enhances dendritic cell activation and further triggers a T helper 1 ( TH1)/TH2 immune response, resulting in pathogen-specific immunological memory against recurrent MRSA infection. Upon second infection, Rp@Al-treated mice show significantly lower bacterial burden, faster abscess recovery, and higher survival under near-lethal infection doses than control mice. Conclusions This innovative multiplex system, with superior photothermal and immunomodulatory effects, presents great potential for the treatment and prevention of drug-resistant bacterial infections.
Jun Xiang,Mengran Xu Techno-Press 2023 Advances in concrete construction Vol.15 No.1
This paper examines the dynamic response of rotating nanodevices under the external harmonic load. The spinning nanosystem is made of nanoscale tubes that rotate around the central nanomotor and is mathematically modeled via high-order beam theory as well as nonclassical nonlocal theory for the size impact. According to the Hamilton principle, the dynamic motion equations are derived, then the time-dependent results are obtained using the Newmark Beta technique along with the generalized differential quadratic method. The presented results are discussed dynamic deflection, resonant frequency, and natural frequency in response to the different applicable parameters, which help develop and produce nanoelectromechanical systems (NEMS) for various applications.