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Lu Ming,Li Min,Luo Tao,Li Yongsui,Wang Mingxin,Xue Huashi,Zhang Mengchen,Chen Qiu 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3
Background Treating large-volume bone defects (LVBD) remains a challenge for orthopedics and maxillofacial surgeons globally. Objective The present study was to aimed investigate the role of Beta-naphthofl avone (BNF) a synthetic fl avonoid on differentiation of osteoblast of human adipose derived stem cells. Results BNF at 1 μM showed a signifi cantly increased ALP activity and rate of cell proliferation compared to control on the 3rd, 7th and 14th day. Also, it was observed that, BNF at 1 μM resulted in signifi cantly increased expression of BSP. On the 14th day of treatment, BNF at all the three treatments resulted in increased levels of OCN. Also, extracellular matrix mineralization levels were recorded to be highest for BNF 1 μM. The levels of Runx2 were higher in 1 μM treated group on the 3rd day compared to other, whereas in contrast the levels were lower on the 7th and 14th day compared to control. BNF at all the three treatments caused a signifi cant decrease in levels of pSTAT3, C/EBP-α and PPAR-γ levels. Conclusion BNF treatment resulted in increased diff erentiation of osteoblast of hASCs by targeting STAT3 pathway.