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RISS 인기검색어
- 검색키워드
- 저자 : Meng Lingjun (검색결과 5 건)
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A Network Load Sensitive Block Placement Strategy of HDFS
( Lingjun Meng ),( Wentao Zhao ),( Haohao Zhao ),( Yang Ding ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.9
This paper investigates and analyzes the default block placement strategy of HDFS. HDFS is a typical representative distributed file system to stream vast amount of data effectively at high bandwidth to user applications. However, the default HDFS block placement policy assumes that all nodes in the cluster are homogeneous, and places blocks with a simple RoundRobin strategy without considering any nodes` resource characteristics, which decreases self-adaptability of the system. The primary contribution of this paper is the proposition of a network load sensitive block placement strategy. We have implemented our algorithm and justify it through extensive simulations and comparison with similar existing studies. The results indicate that our work not only performs much better in the data distribution but also improves write performance more significantly than the others.
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Meng, Lingjun,Park, Jung-Eun,Kim, Tae-Sung,Lee, Eun Hye,Park, Suk-Youl,Zhou, Ming,Bang, Jeong K.,Lee, Kyung S. American Society for Microbiology 2015 Molecular and cellular biology Vol.35 No.15
<P>Serving as microtubule-organizing centers, centrosomes play a key role in forming bipolar spindles. The mechanism of how centrosomes promote bipolar spindle assembly in various organisms remains largely unknown. A recent study with <I>Xenopus laevis</I> egg extracts suggested that the Plk1 ortholog Plx1 interacts with the phospho-T46 (p-T46) motif of <I>Xenopus</I> Cep192 (xCep192) to form an xCep192-mediated xAurA-Plx1 cascade that is critical for bipolar spindle formation. Here, we demonstrated that in cultured human cells, Cep192 recruits AurA and Plk1 in a cooperative manner, and this event is important for the reciprocal activation of AurA and Plk1. Strikingly, Plk1 interacted with Cep192 through either the p-T44 (analogous to <I>Xenopus</I> p-T46) or the newly identified p-S995 motif via its C-terminal noncatalytic polo-box domain. The interaction between Plk1 and the p-T44 motif was prevalent in the presence of Cep192-bound AurA, whereas the interaction of Plk1 with the p-T995 motif was preferred in the absence of AurA binding. Notably, the loss of p-T44- and p-S995-dependent Cep192-Plk1 interactions induced an additive defect in recruiting Plk1 and γ-tubulin to centrosomes, which ultimately led to a failure in proper bipolar spindle formation and mitotic progression. Thus, we propose that Plk1 promotes centrosome-based bipolar spindle formation by forming two functionally nonredundant complexes with Cep192.</P>
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Limei Zhang,Lingjun Meng,Chuanwei Guo,Meixiang Gao,Dong Liu,Xueping Zhang 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.12
Maoer Mountain National Forest Ecological Station is located in Heilongjiang Province. By using the statistical spatial analysis method, which showed that the soil mites community and species richness of mites spatial heterogeneity. Also, which is illustrated that the spatial effect relationship with the environmental factors. The results of crossvariogram and simple Mantel test showed that positive relationships between soil mite communities, specific mite species and environmental factors were detected. Among the environmental factors, soil pH showed significant affects on spatial heterogeneity of soil mite species in both years. When considering the relationships between soil mite species, positive correlations and specific mite species were also observed. Spatial heterogeneities of soil mite communities and most of the soil mite species were regulated by structured factors, in which environmental variables might be important drivers. Thus, it is implied that abundances of soil mite community and most of the soil mite species showed aggregated spatially heterogeneity, and significant relationship between such heterogeneity and environmental factors were detected.
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Putting a bit into the polo-box domain of polo-like kinase 1
Park, Jung-Eun,Kim, Tae-Sung,Meng, Lingjun,Bang, Jeong K.,Kim, Bo Y.,Lee, Kyung S. Korea Basic Science Institute 2015 Journal of analytical science & technology Vol.6 No.1
<P>Polo-like kinase 1 (Plk1) plays key roles in regulating various mitotic processes that are critical for cellular proliferation. A growing body of evidence suggests that Plk1 overexpression is tightly associated with the development of human cancers. Interestingly, various types of cancer cells are shown to be addicted to a high level of Plk1, and the reversal of Plk1 addiction appears to be an effective strategy for selectively killing cancer cells, but not normal cells. Therefore, Plk1 is considered an attractive anticancer drug target. Over the years, a large number of inhibitors that target the catalytic activity of Plk1 have been developed. However, these inhibitors exhibit significant levels of cross-reactivity with related kinases, including Plk2 and Plk3. Consequently, as an alternative approach for developing anti-Plk1 therapeutics, substantial effort is under way to develop inhibitors that target the C-terminal protein–protein interaction domain of Plk1, called the polo-box domain (PBD). In this communication, I will discuss the pros and cons of targeting the PBD in comparison to those of targeting the ATP-binding site within the kinase domain.</P>
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Chen Xiuling,Mo Fulei,Shen Chunyang,Meng Lingjun,Zou Yuxin,Xue Xiaopeng,Cheng Mozhen,Meng Fanyue,Qi Haonan,Wang Aoxue 한국원예학회 2022 Horticulture, Environment, and Biotechnology Vol.63 No.6
NAC proteins in plants respond to stress and play an important role in plant growth regulation. This regulation occurs through a variety of downstream eff ects mediated by plant hormones in response to stress. In this study, we performed a systematic genome-wide analysis of the NAC gene family in tomato based on genome version SL4.0. We identifi ed 99 SlNAC genes by abiotic stress analysis of conserved motifs and gene structure, phylogenetic analysis, cis-element analysis, chromosome localization analysis, synteny relationship and expression pattern analysis. These 99 SlNAC genes were distributed on all 12 chromosomes. Except for genes without introns, there was no signifi cant correlation between gene structures and phylogenetic relationships. Most of the cis-elements identifi ed were associated with plant hormones and environmental responses. There were 77 SlNAC genes that showed no homogeneity between tomato and wild rice, suggesting that these homologous genes arose after the diff erentiation of dicotyledonous and monocotyledonous plants. The comprehensive analysis of the SlNAC gene family provides a valuable resource for studying this gene family in tomato and a foundation for further study of the functional characteristics of these genes.
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