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- 검색키워드
- 저자 : Masaya Hattori (검색결과 4 건)
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Hara, Masanori,Hattori, Daiki,Inukai, Junji,Bae, Byungchan,Hoshi, Takayuki,Hara, Masaya,Miyatake, Kenji,Watanabe, Masahiro American Chemical Society 2013 The journal of physical chemistry. B, Condensed ma Vol.117 No.14
<P>The proton-conductive spots on the membrane surface of sulfonated poly(arylene ether) multiblock copolymer were successfully imaged by current-sensing atomic force microscopy under hydrogen atmosphere at various temperatures and humidities. These spots should be connected to the proton-conductive paths inside the membrane. The average diameter of the spots was approximately 12 nm, consistent with the size of hydrophilic domains observed by transmission electron microscopy. The size of the proton-conducting spots was almost unchanged regardless of the temperature and humidity, whereas the number of the spots increased at higher humidity; the total area of the proton-conducting spots increased accordingly on the membrane surface. This increase in the conducting area at high humidity should be related to the bulk ionic conductivity measured by impedance spectroscopy.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpcbfk/2013/jpcbfk.2013.117.issue-14/jp312041c/production/images/medium/jp-2012-12041c_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp312041c'>ACS Electronic Supporting Info</A></P>
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Smectic A–hexagonal columnar–B7 phase transition of acute-angle bent-core molecules
Lee, Eun-Woo,Hattori, Masaya,Uehara, Fumiya,Tokita, Masatoshi,Kawauchi, Susumu,Watanabe, Junji,Kang, Sungmin The Royal Society of Chemistry 2015 Journal of Materials Chemistry C Vol.3 No.10
<▼1><P>A distinct structural transformation occurs between a 1D layered SmA phase and 2D layer undulated banana phase <I>via</I> a unique hexagonal columnar phase which may result from different molecular packings as a function of temperature.</P></▼1><▼2><P>Acute-angle bent-shaped molecules comprising a 1,7-naphthalene central core, alkylthio terminal chains and long side wings comprising three phenyl rings connected by imine and ester linkages were synthesised. Their distinct mesomorphic properties and phase structures were revealed. Despite their acute shape, these molecules exhibited a polar switchable hexagonal columnar phase (Colh), banana B7 phases and calamitic smectic A (SmA) phase, enabling the first observation of SmA–Colh–B7 and Colh–B7 phase transition behaviours. The formation of a hexagonal columnar phase between the layered smectic A and B7 phases supports the proposed Colh phase model in which a tube-like assembly incorporating smectic layers generates hexagonal columns. Molecular packing in the optically uniaxial SmA phase was also discussed in terms of birefringence. Overall, the structural transformation of one-dimensional SmA layers into deformed hexagonal columnar and B7 phases was found to depend on the combined effects of molecular asymmetry, alkylthio terminal tails and the balance between flexible chain lengths and rigid mesogenic units.</P></▼2>
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Yuka Endo,Akiyo Yoshimura,Masataka Sawaki,Masaya Hattori,Haruru Kotani,Ayumi Kataoka,Nanae Horisawa,Yuri Ozaki,Kazuki Nozawa,Daiki Takatsuka,Ayaka Isogai,Hiroji Iwata 한국유방암학회 2022 Journal of breast cancer Vol.25 No.4
Purpose: Safely postponing the use of chemotherapy is important for quality of life maintenance in patients with hormone receptor-positive advanced breast cancer. In previous studies, a combination of cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) and fulvestrant prolonged the time to chemotherapy (TTC). In this study, we used real-world data to evaluate TTC in the context of CDK4/6i therapy. Methods: We performed a retrospective chart review of women with estrogen receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer treated at the Aichi Cancer Center Hospital. The patients were categorized into having received CDK4/6i therapy first (n = 41), second (n = 33), and none at all (n = 67). The change in TTC among the groups was examined. Results: The median follow-up time was 13.8, 27.5, and 30.3 months in the CDK4/6i (first), CDK4/6i (second), and non-CDK4/6i groups, respectively. The median progression-free survival (PFS) with first-line therapy for metastasis was 30.0, 11.9, and 13.0 months, respectively (CDK4/6i [first] vs. non-CDK4/6i; p = 0.018, CDK4/6i [second] vs. non-CDK4/6i; p = 0.383). The median TTC was not reached in the CDK4/6i (first) group, was 39.1 months in the CDK4/6i (second) group, and was 44.2 months in the non-CDK4/6i group (CDK4/6i [first] vs. non-CDK4/6i; p = 0.880; CDK4/6i [second] vs. non-CDK4/6i; p = 0.407). The non-CDK4/6i group with TTC ≥ 60 months included more cases of secondary endocrine therapy resistance (p = 0.017), no perioperative chemotherapy (p = 0.021), and a longer disease-free interval (p = 0.093). Conclusion: Although PFS was significantly longer in the CDK4/6i (first) group than in the non-CDK4/6i group, TTC did not significantly differ among the three groups in real-world data. The non-CDK4/6i group showed a long TTC in patients with late recurrence and low risk at the primary lesion site, who benefited greatly from hormone monotherapy.
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Daiki Takatsuka,Akiyo Yoshimura,Masataka Sawaki,Masaya Hattori,Haruru Kotani,Ayumi Kataoka,Nanae Horisawa,Yuri Ozaki,Yuka Endo,Kazuki Nozawa,Hiroji Iwata 한국유방암학회 2023 Journal of breast cancer Vol.26 No.2
Purpose: Fine-needle aspiration cytology (FNAC) of axillary lymph nodes (AxLNs) is performed to diagnose nodal metastasis in patients with breast cancer. Although the sensitivity of ultrasound-guided FNAC for identifying AxLN metastasis is in the range of 36%–99%, whether sentinel lymph node biopsy (SLNB) should be performed for neoadjuvant chemotherapy (NAC) patients with negative FNAC results is uncertain. This study aimed to determine the role of FNAC before NAC in the evaluation and management of AxLN in early breast cancer patients. Methods: We retrospectively analyzed 3,810 clinically node-negative (a lymph node with no clinical metastasis without FNAC or radiological suspicion of metastasis with negative FNAC results) patients with breast cancer who underwent SLNB between 2008 and 2019. We compared the positivity rate of sentinel lymph nodes (SLNs) between patients who received and those who did not receive NAC with negative FNAC results or without FNAC and axillary recurrence rate in the neoadjuvant group with negative SLNB results. Results: In the non-neoadjuvant (primary surgery) group, the positivity rate of SLNs in patients with negative FNAC results was higher than that in patients without FNAC (33.2% vs. 12.9%; p < 0.001). However, the SLN positivity rate of patients with negative FNAC results (false-negative rate for FNAC) in the neoadjuvant group was lower than that in the primary surgery group (3.0% vs. 33.2%; p < 0.001). After a median follow-up of 3 years, one axillary nodal recurrence was observed, which was a case from the neoadjuvant non-FNAC group. None of the patients in the neoadjuvant group with negative FNAC results had axillary recurrence. Conclusion: The false-negative rate for FNAC in the primary surgery group was high; however, SLNB was the proper axillary staging procedure for NAC patients who have clinically suspicious AxLN metastases on radiologic examination but negative FNAC results.
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