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- 저자 : Maryam Dolatshahi (검색결과 1 건)
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Maryam Dolatshahi,Ahmad Reza Bahrami,Qaiser Iftikhar Sheikh,Mohsen Ghanbari,Maryam M. Matin 대한약학회 2024 Archives of Pharmacal Research Vol.47 No.1
Gastric cancer (GC) is one of the most prevalent malignancies in the world, with a high mortality rate in both womenand men. Conventional treatments, like chemotherapy, radiotherapy and surgery, are facing some drawbacks like acquireddrug resistance and various side eff ects, leading to cancer recurrence and increased morbidity; thus, development of novelapproaches in targeted therapy would be very benefi cial. Exosomes, extracellular vesicles with a size distribution of sub-150 nm, interplay in physiological and pathophysiological cell–cell communications and can pave the way for targeted cancertherapy. Accumulating pieces of evidence have indicated that exosomes derived from mesenchymal stem cells (MSC-EXs)can act as a double-edged sword in some cancers. The purpose of this review is to assess the diff erences between stem celltherapy and exosome therapy. Moreover, our aim is to demonstrate how naïve MSCs transform into GC-MSCs in the tumormicroenvironment. Additionally, the tumorigenic and anti-proliferation eff ects of MSC-EXs derived from diff erent originswere investigated. Finally, we suggest potential modifi cations and combination options that involve utilizing MSC-EXs fromthe foreskin and umbilical cord as promising sources to enhance the effi cacy of gastric cancer treatment. This approach ispresented in contrast to bone marrow cells, which are more heterogeneous, age-related, and are also easily aff ected by thepatient's circulation system.
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